The advantages of the model organism Drosophila melanogaster, including low genetic
redundancy, functional simplicity, and the ability to conduct large-scale genetic screens …

Sleep–wake cycles are known to be disrupted in people with neurodegenerative disorders.
These findings are now supported by data from animal models for some of these disorders …

Period determination in the mammalian circadian clock involves the turnover rate of the
repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 …

Circadian rhythms are controlled by a system of negative and positive genetic feedback
loops composed of clock genes. Although many genes have been implicated in these …

Circadian clocks temporally organize behavior and physiology across the 24-h day. Great
progress has been made in understanding the molecular basis of timekeeping, with a focus …

Evidence for transcriptional feedback in circadian timekeeping is abundant, yet little is
known about the mechanisms underlying translational control. We found that ATAXIN-2 …

The NLRP 3 inflammasome is involved in the innate immune response during inflammation.
Moreover, melatonin blunts the NF‐κB/NLRP 3 connection during sepsis. Thus, we …

Research into the molecular mechanisms of eukaryotic circadian clocks has proceeded at
an electrifying pace. In this review, we discuss advances in our understanding of the …

A central question in the circadian biology field concerns the mechanisms that translate~ 24‐
hr oscillations of the molecular clock into overt rhythms. Drosophila melanogaster is a …

As one of the most successful intracellular symbiotic bacteria, Wolbachia can infect many
arthropods and nematodes. Wolbachia infection usually affects the reproduction of their …