Neuropeptide Y peptide family and cancer: Antitumor therapeutic strategies

ML Sánchez, FD Rodríguez, R Coveñas - International Journal of …, 2023 - mdpi.com
Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …

Neuropeptides in Cancer: Friend and Foe?

Y Wu, A Berisha, JC Borniger - Advanced Biology, 2022 - Wiley Online Library
Neuropeptides are small regulatory molecules found throughout the body, most notably in
the nervous, cardiovascular, and gastrointestinal systems. They serve as neurotransmitters …

Histone serotonylation regulates ependymoma tumorigenesis

HC Chen, P He, M McDonald, MR Williamson… - Nature, 2024 - nature.com
Bidirectional communication between tumours and neurons has emerged as a key facet of
the tumour microenvironment that drives malignancy,. Another hallmark feature of cancer is …

Multi-omics integration analysis of GPCRs in pan-cancer to uncover inter-omics relationships and potential driver genes

S Li, X Chen, J Chen, B Wu, J Liu, Y Guo, M Li… - Computers in Biology …, 2023 - Elsevier
G protein-coupled receptors (GPCRs) are the largest drug target family. Unfortunately,
applications of GPCRs in cancer therapy are scarce due to very limited knowledge …

Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread

D Sigorski, W Wesołowski, A Gruszecka… - Journal of Cancer …, 2023 - Springer
Abstract Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many
biological mechanisms important in regulation of cell growth and survival. The aim of this …

Thrombospondin-4 is a soluble dermal inflammatory signal that selectively promotes fibroblast migration and keratinocyte proliferation for skin regeneration and …

M Klaas, K Mäemets-Allas, E Heinmäe… - Frontiers in cell and …, 2021 - frontiersin.org
Thrombospondin-4 (THBS4) is a non-structural extracellular matrix molecule associated with
tissue regeneration and a variety of pathological processes characterized by increased cell …

NPY stimulates cholesterol synthesis acutely by activating the SREBP2-HMGCR pathway through the Y1 and Y5 receptors in murine hepatocytes

F Chen, Y Zhou, K Yang, M Shen, Y Wang - Life Sciences, 2020 - Elsevier
Aims The development of non-alcoholic fatty liver disease (NAFLD) is partially attributed to
disturbance in cholesterol metabolism and sympathetic overactivity. Excessive levels of the …

Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer

P Dietrich, L Wormser, V Fritz, T Seitz… - The Journal of …, 2020 - Am Soc Clin Investig
Hepatocellular carcinoma (HCC) is clearly age-related and represents one of the deadliest
cancer types worldwide. As a result of globally increasing risk factors including metabolic …

Retracted: MCM3AP-AS1 KD inhibits proliferation, invasion, and migration of PCa cells via DNMT1/DNMT3 (A/B) methylation-mediated upregulation of NPY1R

X Li, J Lv, S Liu - Molecular Therapy-Nucleic Acids, 2020 - cell.com
Prostate cancer (PCa) is a heterogeneous tumor that commonly occurs among males
worldwide. This study explored the potential role that long non-coding RNA MCM3AP …

Correlation of transcriptomics and FDG-PET SUVmax indicates reciprocal expression of stemness-related transcription factor and neuropeptide signaling pathways in …

C Prexler, MS Knape, J Erlewein-Schweizer, W Roll… - Cancers, 2022 - mdpi.com
Simple Summary Survival rates for metastatic or early recurring Ewing sarcoma (EwS) are
dismal, and therapies have severe side and long-term effects. Both aspects require new …