Background: Measurement of plasma total homocysteine has become common as new
methods have been introduced. A wide range of disorders are associated with increased …

Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for
atherosclerosis and vascular disease. Homocysteine is a branch‐point intermediate of …

Context: It has been suggested that elevated total plasma homocysteine levels are
associated with the risk of venous thrombosis. Objective: To assess the relationship of …

Genetic and environmental factors interact in determining the risk of venous
thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor …

We conducted a systematic and comprehensive meta-analysis on all candidate genes to
assess their genetic contribution to the aetiology of venous thromboembolism …

Leukemias commonly arise as a result of DNA translocations, inversions, or deletions in
genes regulating blood cell development or homeostasis. Folate deficiency has been …

MTHFR polymorphism testing is frequently ordered by physicians as part of the clinical
evaluation for thrombophilia. It was previously hypothesized that reduced enzyme activity of …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

The pathogenesis of spontaneous abortion is complex, presumably involving the interaction
of several genetic and environmental factors. The methylenetetrahydrofolate reductase …

MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive
function. Variation in the sequence of MTHFR has been implicated in subfertility, but …