The reactive functionalities of drugs that engage in covalent interactions with the
enzyme/receptor residue in either a reversible or an irreversible manner are …

Peptides are highly potent biological active compounds with excellent selectivity and
binding, but they have some drawbacks (eg, low stability in vivo because of the enzymatic …

Background Thyroid eye disease (TED) is the most common orbital pathology that occurs in
up to 50% of patients with Graves' disease. Herein, we aimed at discovering the possible …

For over 50 years of azapeptide synthetic techniques, developments have renewed the field
of peptidomimetic therapeutics. Azapeptides are close surrogates of natural peptides: they …

COVID-19, the disease responsible for the recent pandemic, is caused by a novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main protease (Mpro) of …

As a hydrolase, chymotrypsin (CHT) is involved in many physiological activities, and its
abnormal activity is closely related to diabetes, pancreatic fibrosis, chronic pancreatitis and …

Azapeptides contain at least one aza-amino acid, where the α-carbon has been replaced by
a nitrogen atom, and have found broad applicability in fields ranging from medicinal …

The structures of the title compounds 2-hydroxy-N′-methylacetohydrazide, 1, and 2-
hydroxy-N-methylacetohydrazide, 2, both C3H8N2O2, as regioisomers differ in the position …

The use of peptides as therapeutic agents is a widespread strategy in the medicinal field, in
part due to pharmacological properties conferred by their three-dimensional structures …