Human beings are adept at discerning relevant information from complex systems by processing visual information. Similarly, as scientists labor to understand the fundamental …
Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating …
K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1 Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …
This review focuses on recent advances in instrumentation, techniques, and applications of the highest resolution mass analyzers (multipass time of flight (TOF), orbitrap, and Fourier …
A Zavalin, J Yang, K Hayden, M Vestal… - Analytical and …, 2015 - Springer
We have achieved protein imaging mass spectrometry capabilities at sub-cellular spatial resolution and at high acquisition speed by integrating a transmission geometry ion source …
A Walch, S Rauser, SO Deininger, H Höfler - Histochemistry and cell …, 2008 - Springer
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful tool for investigating the distribution of proteins and small molecules within …
EH Seeley, RM Caprioli - Proceedings of the National …, 2008 - National Acad Sciences
Imaging MS (IMS) is an emerging technology that permits the direct analysis and determination of the distribution of molecules in tissue sections. Biological molecules such …
S Altmäe, FJ Esteban, A Stavreus-Evers… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND 'Omics' high-throughput analyses, including genomics, epigenomics, transcriptomics, proteomics and metabolomics, are widely applied in human endometrial …
The molecular complexity of biological tissue and the spatial and temporal variation in the biological processes involved in human disease requires new technologies and new …