Mechanisms of implantation: strategies for successful pregnancy

J Cha, X Sun, SK Dey - Nature medicine, 2012 - nature.com
Physiological and molecular processes initiated during implantation for pregnancy success
are complex but highly organized. This review primarily highlights adverse ripple effects …

Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

[HTML][HTML] Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution

PD Piehowski, Y Zhu, LM Bramer, KG Stratton… - Nature …, 2020 - nature.com
Biological tissues exhibit complex spatial heterogeneity that directs the functions of
multicellular organisms. Quantifying protein expression is essential for elucidating …

Mass spectrometric imaging for biomedical tissue analysis

K Chughtai, RMA Heeren - Chemical reviews, 2010 - ACS Publications
A mass spectrometer is described as the smallest weighing scale ever used in the world. 1
Mass spectrometry (MS) is a unique technique that has an interdisciplinary nature, which …

High resolution mass spectrometry

F Xian, CL Hendrickson, AG Marshall - Analytical chemistry, 2012 - ACS Publications
This review focuses on recent advances in instrumentation, techniques, and applications of
the highest resolution mass analyzers (multipass time of flight (TOF), orbitrap, and Fourier …

Tissue protein imaging at 1 μm laser spot diameter for high spatial resolution and high imaging speed using transmission geometry MALDI TOF MS

A Zavalin, J Yang, K Hayden, M Vestal… - Analytical and …, 2015 - Springer
We have achieved protein imaging mass spectrometry capabilities at sub-cellular spatial
resolution and at high acquisition speed by integrating a transmission geometry ion source …

MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology

A Walch, S Rauser, SO Deininger, H Höfler - Histochemistry and cell …, 2008 - Springer
Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful tool for investigating the distribution of proteins and small molecules within …

Molecular imaging of proteins in tissues by mass spectrometry

EH Seeley, RM Caprioli - Proceedings of the National …, 2008 - National Acad Sciences
Imaging MS (IMS) is an emerging technology that permits the direct analysis and
determination of the distribution of molecules in tissue sections. Biological molecules such …

Guidelines for the design, analysis and interpretation of 'omics' data: focus on human endometrium

S Altmäe, FJ Esteban, A Stavreus-Evers… - Human reproduction …, 2014 - academic.oup.com
BACKGROUND 'Omics' high-throughput analyses, including genomics, epigenomics,
transcriptomics, proteomics and metabolomics, are widely applied in human endometrial …

MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives

EH Seeley, RM Caprioli - Trends in biotechnology, 2011 - cell.com
The molecular complexity of biological tissue and the spatial and temporal variation in the
biological processes involved in human disease requires new technologies and new …