Complete and incomplete hepatitis B virus particles: formation, function, and application

J Hu, K Liu - Viruses, 2017 - mdpi.com
Hepatitis B virus (HBV) is a para-retrovirus or retroid virus that contains a double-stranded
DNA genome and replicates this DNA via reverse transcription of a RNA pregenome. Viral …

Hepatitis B virus: advances in prevention, diagnosis, and therapy

MH Nguyen, G Wong, E Gane, JH Kao… - Clinical microbiology …, 2020 - Am Soc Microbiol
Currently, despite the use of a preventive vaccine for several decades as well as the use of
effective and well-tolerated viral suppressive medications since 1998, approximately 250 …

Mechanism of hepatitis B virus cccDNA formation

L Wei, A Ploss - Viruses, 2021 - mdpi.com
Hepatitis B virus (HBV) remains a major medical problem affecting at least 257 million
chronically infected patients who are at risk of developing serious, frequently fatal liver …

[HTML][HTML] Hepatitis B virus molecular biology and pathogenesis

RJ Lamontagne, S Bagga, MJ Bouchard - Hepatoma research, 2016 - ncbi.nlm.nih.gov
As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to
viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular …

Revisiting hepatitis B virus: challenges of curative therapies

J Hu, U Protzer, A Siddiqui - Journal of virology, 2019 - Am Soc Microbiol
With a yearly death toll of 880,000, hepatitis B virus (HBV) remains a major health problem
worldwide, despite an effective prophylactic vaccine and well-tolerated, effective antivirals …

Interferon and interferon-stimulated genes in HBV treatment

Q Li, B Sun, Y Zhuo, Z Jiang, R Li, C Lin, Y Jin… - Frontiers in …, 2022 - frontiersin.org
Human hepatitis B virus (HBV) is a small enveloped DNA virus with a complex life cycle. It is
the causative agent of acute and chronic hepatitis. HBV can resist immune system …

New antiviral targets for innovative treatment concepts for hepatitis B virus and hepatitis delta virus

D Durantel, F Zoulim - Journal of hepatology, 2016 - Elsevier
Current therapies of chronic hepatitis B (CHB) remain limited to pegylated-interferon-alpha
(PegIFN-α) or any of the five approved nucleos (t) ide analogues (NUC) treatments. While …

Capsid assembly modulators as antiviral agents against HBV: molecular mechanisms and clinical perspectives

V Taverniti, G Ligat, Y Debing, DB Kum… - Journal of clinical …, 2022 - mdpi.com
Despite a preventive vaccine being available, more than 250 million people suffer from
chronic hepatitis B virus (HBV) infection, a major cause of liver disease and HCC. HBV …

Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B

U Viswanathan, N Mani, Z Hu, H Ban, Y Du, J Hu… - Antiviral research, 2020 - Elsevier
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …

Hepatitis B virus: virology, molecular biology, life cycle and intrahepatic spread

P Karayiannis - Hepatology international, 2017 - Springer
Hepatitis B virus is a member of the Hepadnaviridae family and responsible for causing
acute and chronic hepatitis in humans. The current estimates of people chronically infected …