Recent advances in the reciprocal regulation of m6A modification with non-coding RNAs and its therapeutic application in acute myeloid leukemia

J Yang, F Liang, F Zhang, H Zhao, Q Gong… - Pharmacology & …, 2024 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is one of the most common modifications of RNA in
eukaryotic cells and is involved in mRNA metabolism, including stability, translation …

Recent advances of m6A methylation in skeletal system disease

J Liang, Q Yi, Y Liu, J Li, Z Yang, W Sun… - Journal of Translational …, 2024 - Springer
Skeletal system disease (SSD) is defined as a class of chronic disorders of skeletal system
with poor prognosis and causes heavy economic burden. m6A, methylation at the N6 …

A multiomics dataset for the study of RNA modifications in human macrophage differentiation and polarisation

N Pinello, R Song, Q Lee, E Calonne, M Larance… - Scientific Data, 2024 - nature.com
RNA modifications have emerged as central regulators of gene expression programs.
Amongst RNA modifications are N6-methyladenosine (m6A) and RNA 5 …

Dynamic changes in RNA m6A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation

N Pinello, R Song, Q Lee, E Calonne, KL Duan… - Cellular and Molecular …, 2024 - Springer
RNA modifications are essential for the establishment of cellular identity. Although
increasing evidence indicates that RNA modifications regulate the innate immune response …

Genetically Encoded Trensor Circuits Report HeLa Cell Treatment with Polyplexed Plasmid DNA and Small-Molecule Transfection Modulators

C Redwood-Sawyerr, G Howe… - ACS Synthetic …, 2024 - ACS Publications
HeLa cell transfection with plasmid DNA (pDNA) is widely used to materialize biologicals
and as a preclinical test of nucleic acid-based vaccine efficacy. We sought to genetically …

Unraveling the cross‐talk between N6‐methyladenosine modification and non‐coding RNAs in breast cancer: Mechanisms and clinical implications

X Liu, X Xie, C Sui, X Liu, M Song, Q Luo… - … Journal of Cancer, 2024 - Wiley Online Library
In recent years, breast cancer (BC) has surpassed lung cancer as the most common
malignant tumor worldwide and remains the leading cause of cancer death in women. The …

N6-methyladenosine (m6A) RNA modification in chronic myeloid leukemia: unveiling a novel therapeutic target

G Fernandez Rodriguez, M Tarullo, A Fatica - Cellular and Molecular Life …, 2024 - Springer
Abstract N6-methyladenosine (m6A), the most prevalent internal mRNA modification, plays a
critical role in physiological processes by regulating gene expression through modulation of …