It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …

Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …

Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification …

Gene–environment correlations affect associations between genetic variants and complex
traits in genome-wide association studies (GWASs). Here we showed in up to 43,516 British …

ABSTRACT A forest species of millipede belonging to the Order Spirobolida found along the
eastern coast of southern Africa were tested for size assortative mating. The objectives …

Urban-living individuals are exposed to many environmental factors that may combine and
interact to influence mental health. While individual factors of an urban environment have …

Estimates from Mendelian randomization studies of unrelated individuals can be biased due
to uncontrolled confounding from familial effects. Here we describe methods for within-family …

Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …

Sequence variants in the parental genomes that are not transmitted to a child (the proband)
are often ignored in genetic studies. Here we show that nontransmitted alleles can affect a …

Accurate prediction of an individual's phenotype from their DNA sequence is one of the great
promises of genomics and precision medicine. We extend a powerful individual-level data …