Recent advances in chitosan and its derivatives in cancer treatment

J Ding, Y Guo - Frontiers in Pharmacology, 2022 - frontiersin.org
Cancer has become a main public health issue globally. The conventional treatment
measures for cancer include surgery, radiotherapy and chemotherapy. Among the various …

Targeting anticancer immunity in oral cancer: Drugs, products, and nanoparticles

L Qin, J Wu - Environmental Research, 2023 - Elsevier
Oral cavity carcinomas are the most frequent malignancies among head and neck
malignancies. Oral tumors include not only oral cancer cells with different potency and …

CD8 T cell score as a prognostic biomarker for triple negative breast cancer

M Oshi, M Asaoka, Y Tokumaru, L Yan… - International journal of …, 2020 - mdpi.com
CD8 T cell is an essential component of tumor-infiltrating lymphocytes (TIL) and tumor
immune microenvironment (TIME). Using the xCell CD8 T cell score of whole tumor gene …

MYC targets scores are associated with cancer aggressiveness and poor survival in ER-positive primary and metastatic breast cancer

A Schulze, M Oshi, I Endo, K Takabe - International journal of molecular …, 2020 - mdpi.com
MYC is one of the most studied oncogenes that is known to promote cell proliferation. We
utilized MYC targets v1 and MYC targets v2 scores of gene set variation analysis and …

Intra-tumoral angiogenesis is associated with inflammation, immune reaction and metastatic recurrence in breast cancer

M Oshi, S Newman, Y Tokumaru, L Yan… - International journal of …, 2020 - mdpi.com
Angiogenesis is one of the hallmarks of cancer. We hypothesized that intra-tumoral
angiogenesis correlates with inflammation and metastasis in breast cancer patients. To test …

High G2M pathway score pancreatic cancer is associated with worse survival, particularly after margin-positive (R1 or R2) resection

M Oshi, S Newman, Y Tokumaru, L Yan, R Matsuyama… - Cancers, 2020 - mdpi.com
Simple Summary The G2M checkpoint pathway is a critical step in the cell cycle, which is
one of the hallmarks in cancer. We investigated clinical relevance of the G2M pathway in …

[HTML][HTML] FGF9/FGFR1 promotes cell proliferation, epithelial-mesenchymal transition, M2 macrophage infiltration and liver metastasis of lung cancer

MM Chang, SZ Wu, SH Yang, CC Wu, CY Wang… - Translational …, 2021 - Elsevier
Abstract Fibroblast growth factors 9 (FGF9) modulates cell proliferation, differentiation and
motility for development and repair in normal cells. Abnormal activation of FGF9 signaling is …

Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple‐Negative Subtype of Breast Cancer Patients

M Oshi, S Newman, Y Tokumaru, L Yan… - Journal of …, 2020 - Wiley Online Library
Inflammation has been linked with cancer, but whether it is part of the problem or part of the
solution remains to be a matter of debate in breast cancer. Our group and others have …

Intratumoral adipocyte-high breast cancer enrich for metastatic and inflammation-related pathways but associated with less cancer cell proliferation

Y Tokumaru, M Oshi, E Katsuta, L Yan… - International journal of …, 2020 - mdpi.com
Cancer-associated adipocytes are known to cause inflammation, leading to cancer
progression and metastasis. The clinicopathological and transcriptomic data from 2256 …

[HTML][HTML] Low intratumoral genetic neutrophil-to-lymphocyte ratio (NLR) is associated with favorable tumor immune microenvironment and with survival in triple …

Y Tokumaru, M Oshi, V Murthy, W Tian… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Patients with triple negative breast cancer (TNBC) have a poor prognosis. A novel
prognostic biomarker may guide management by appropriately selecting patients for …