The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

Abstract Large Granular Lymphocyte (LGL) Leukemia is a rare, heterogeneous even more
that once thought, chronic lymphoproliferative disorder characterized by the clonal …

Purpose: Develop a novel therapeutic strategy for patients with subtypes of mature T-cell
and NK-cell neoplasms. Experimental Design: Primary specimens, cell lines, patient-derived …

Human aging is marked by the emergence of a tapestry of clonal expansions in dividing
tissues, particularly evident in blood as clonal hematopoiesis (CH). CH, linked to cancer risk …

Large granular lymphocyte leukemia (LGLL) is a chronic lymphoproliferative disorder
characterized by the proliferation of T or NK cytotoxic cells in the peripheral blood, the …

Introduction Large granular lymphocytic (LGL) leukemia is a rare lymphoproliferative
disorder characterized by an expansion of clonal T or NK lymphocytes. Neutropenia-related …

Patients with T-and natural killer (NK)-cell neoplasms frequently have somatic STAT5B gain-
of-function mutations. The most frequent STAT5B mutation is STAT5B N642H, which is …

Epstein-Barr virus (EBV) is the oncogenic driver of multiple cancers. However, the
underlying mechanism of virus-cancer immunological interaction during disease …

Simple Summary The clonal expansions of large granular lymphocytes are frequently
detected in a wide spectrum of hematological and immune diseases. This clinical overlap …