How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation
SJ Renaud, MJ Jeyarajah - Cellular and Molecular Life Sciences, 2022 - Springer
In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …
The evolutionary dynamics of human endogenous retroviral families
N Bannert, R Kurth - Annu. Rev. Genomics Hum. Genet., 2006 - annualreviews.org
The capacity to integrate into the chromosomal DNA of germ-line cells has endowed
retroviruses with the potential to be vertically transmitted from generation to generation and …
retroviruses with the potential to be vertically transmitted from generation to generation and …
Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with …
A Vargas, S Zhou, M Éthier‐Chiasson… - The FASEB …, 2014 - Wiley Online Library
Exosomes are extracellular vesicles that mediate intercellular communication and are
involved in several biological processes. The objective of our study was to determine …
involved in several biological processes. The objective of our study was to determine …
Endogenous retrovirus-encoded Syncytin-2 contributes to exosome-mediated immunosuppression of T cells
AG Lokossou, C Toudic, PT Nguyen… - Biology of …, 2020 - academic.oup.com
Modulation of the activation status of immune cell populations during pregnancy depends on
placental villous cytotrophoblast (VCT) cells and the syncytiotrophoblast (STB). Failure in the …
placental villous cytotrophoblast (VCT) cells and the syncytiotrophoblast (STB). Failure in the …
Impaired cytotrophoblast cell–cell fusion is associated with reduced Syncytin and increased apoptosis in patients with placental dysfunction
M Langbein, R Strick, PL Strissel, N Vogt… - Molecular …, 2008 - Wiley Online Library
Abstract Preeclampsia (PE), Hemolysis Elevated Liver Enzymes and Low Platelets (HELLP)‐
syndrome, and intrauterine growth restriction (IUGR) are associated with abnormal …
syndrome, and intrauterine growth restriction (IUGR) are associated with abnormal …
The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes
JM Tolosa, JE Schjenken, VL Clifton, A Vargas… - Placenta, 2012 - Elsevier
OBJECTIVES: To examine whether syncytin-1 has immune regulatory functions and is
carried by human placental exosomes. Further, to examine whether corticotropin-releasing …
carried by human placental exosomes. Further, to examine whether corticotropin-releasing …
The human endogenous retrovirus link between genes and environment in multiple sclerosis and in multifactorial diseases associating neuroinflammation
H Perron, A Lang - Clinical reviews in allergy & immunology, 2010 - Springer
Endogenous retroviruses represent about 8% of the human genome and belong to the
superfamily of transposable and retrotransposable genetic elements. Altogether, these …
superfamily of transposable and retrotransposable genetic elements. Altogether, these …
Virus-free method to control and enhance extracellular vesicle cargo loading and delivery
S Bui, J Dancourt, G Lavieu - ACS Applied Bio Materials, 2023 - ACS Publications
Extracellular vesicles (EVs)─ including exosomes and microvesicles─ are involved in cell–
cell communication. EVs encapsulate different types of molecules such as proteins or …
cell communication. EVs encapsulate different types of molecules such as proteins or …
Proliferation and cell–cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-β
R Strick, S Ackermann, M Langbein, J Swiatek… - Journal of molecular …, 2007 - Springer
Endometrial carcinomas (EnCa) predominantly represent a steroid hormone-driven tumor
initiated from prestages. The human endogenous retrovirus HERV-W envelope gene …
initiated from prestages. The human endogenous retrovirus HERV-W envelope gene …
Redox-dependent thiol modifications: implications for the release of extracellular vesicles
BJ Benedikter, AR Weseler, EFM Wouters… - Cellular and Molecular …, 2018 - Springer
Extracellular vesicles (EVs), including microvesicles and exosomes, are emerging as
important regulators of homeostasis and pathophysiology. During pro-inflammatory and pro …
important regulators of homeostasis and pathophysiology. During pro-inflammatory and pro …