Phosphatidylethanolamine (PE) is the second most abundant glycerophospholipid in
eukaryotic cells. The existence of four only partially redundant biochemical pathways that …

Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related
membrane aminophospholipids. In mammalian cells, PS is required for targeting and …

Technological developments, especially in mass spectrometry and bioinformatics, have
revealed that living cells contain thousands rather than dozens of different lipids [for …

Communication between organelles is an important feature of all eukaryotic cells. To
uncover components involved in mitochondria/endoplasmic reticulum (ER) junctions, we …

Due to its genetic tractability and increasing wealth of accessible data, the yeast
Saccharomyces cerevisiae is a model system of choice for the study of the genetics …

Mitochondria are dynamic organelles whose functional integrity requires a coordinated
supply of proteins and phospholipids. Defined functions of specific phospholipids, like the …

Mitochondrial structure and function are influenced by the unique phospholipid composition
of its membranes. While mitochondria contain all the major classes of phospholipids, recent …

To broadly explore mitochondrial structure and function as well as the communication of
mitochondria with other cellular pathways, we constructed a quantitative, high-density …

Mitochondrial dysfunction is implicated in neurodegenerative, cardiovascular, and metabolic
disorders, but the role of phospholipids, particularly the nonbilayer-forming lipid …

Mitochondria are complex organelles with two membranes. Their architecture is determined
by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and …