Candidate biomarkers in psychiatric disorders: state of the field

A Abi‐Dargham, SJ Moeller, F Ali… - World …, 2023 - Wiley Online Library
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

An umbrella review of candidate predictors of response, remission, recovery, and relapse across mental disorders

M Solmi, S Cortese, G Vita, M De Prisco, J Radua… - Molecular …, 2023 - nature.com
We aimed to identify diagnosis-specific/transdiagnostic/transoutcome multivariable
candidate predictors (MCPs) of key outcomes in mental disorders. We conducted an …

A Systematic Evaluation of Machine Learning–Based Biomarkers for Major Depressive Disorder

NR Winter, J Blanke, R Leenings, J Ernsting… - JAMA …, 2024 - jamanetwork.com
Importance Biological psychiatry aims to understand mental disorders in terms of altered
neurobiological pathways. However, for one of the most prevalent and disabling mental …

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

M Garcia-Argibay, Y Zhang-James, S Cortese… - Molecular …, 2023 - nature.com
Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous disorder with a high
degree of psychiatric and physical comorbidity, which complicates its diagnosis in childhood …

Multi-omics data integration methods and their applications in psychiatric disorders

A Sathyanarayanan, TT Mueller, MA Moni… - European …, 2023 - Elsevier
To study mental illness and health, in the past researchers have often broken down their
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …

Evidence of questionable research practices in clinical prediction models

N White, R Parsons, G Collins, A Barnett - BMC medicine, 2023 - Springer
Background Clinical prediction models are widely used in health and medical research. The
area under the receiver operating characteristic curve (AUC) is a frequently used estimate to …

[HTML][HTML] Implementing precision methods in personalizing psychological therapies: Barriers and possible ways forward

AK Deisenhofer, M Barkham, ET Beierl… - Behaviour research and …, 2024 - Elsevier
Personalization of psychological therapies has always been used by clinicians and
describes all efforts to select, adjust, or modify a treatment for the individual to improve …

Sample size requirements are not being considered in studies developing prediction models for binary outcomes: a systematic review

P Dhiman, J Ma, C Qi, G Bullock, JC Sergeant… - BMC Medical Research …, 2023 - Springer
Background Having an appropriate sample size is important when developing a clinical
prediction model. We aimed to review how sample size is considered in studies developing …

Evaluation of risk of bias in neuroimaging-based artificial intelligence models for psychiatric diagnosis: a systematic review

Z Chen, X Liu, Q Yang, YJ Wang, K Miao… - JAMA network …, 2023 - jamanetwork.com
Importance Neuroimaging-based artificial intelligence (AI) diagnostic models have
proliferated in psychiatry. However, their clinical applicability and reporting quality (ie …

Sampling inequalities affect generalization of neuroimaging-based diagnostic classifiers in psychiatry

Z Chen, B Hu, X Liu, B Becker, SB Eickhoff, K Miao… - BMC medicine, 2023 - Springer
Background The development of machine learning models for aiding in the diagnosis of
mental disorder is recognized as a significant breakthrough in the field of psychiatry …