Peptides as a therapeutic modality attract much attention due to their synthetic accessibility,
high degree of specific binding, and the ability to target protein surfaces traditionally …

There is great need for stand-alone luminescence-based chemosensors that exemplify
selectivity, sensitivity, and applicability and that overcome the challenges that arise from …

In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

Peptide macrocyclization has traditionally relied on lactam, lactone and disulfide bond-
forming reactions that aim at introducing conformational constraints into small peptide …

This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Transition metal‐catalyzed C− H activation is a step‐economical strategy for peptide
functionalization. Herein, we report the method of late‐stage peptide ligation and …

Transition‐metal‐catalyzed C− H activation has shown potential in the functionalization of
peptides with expanded structural diversity. Herein, the development of late‐stage peptide …

Inspired by nature's wide range of oxidation-induced modifications to install cross-links and
cycles at tyrosine (Tyr) and other phenol-containing residue side chains, we report a Tyr …

The growing emphasis on macrocycles in engaging difficult therapeutic targets such as
protein–protein interactions and GPCRs via preferential adaptation of bioactive and cell …

The selective modification of α-amino acids and peptides constitutes a pivotal arena for
accessing new peptide-based materials and therapeutics. In recent years, visible light …