Carbon Nanomaterial Fluorescent Probes and Their Biological Applications

AT Krasley, E Li, JM Galeana, C Bulumulla… - Chemical …, 2024 - ACS Publications
Fluorescent carbon nanomaterials have broadly useful chemical and photophysical
attributes that are conducive to applications in biology. In this review, we focus on materials …

The Janus of Protein Corona on nanoparticles for tumor targeting, immunotherapy and diagnosis

X Wang, W Zhang - Journal of Controlled Release, 2022 - Elsevier
The therapeutics based on nanoparticles (NPs) are considered as the promising strategy for
tumor detection and treatment. However, one of the most challenges is the adsorption of …

Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning

M Kim, C Chen, P Wang, JJ Mulvey, Y Yang… - Nature Biomedical …, 2022 - nature.com
Serum biomarkers are often insufficiently sensitive or specific to facilitate cancer screening
or diagnostic testing. In ovarian cancer, the few established serum biomarkers are highly …

Rapid SARS-CoV-2 spike protein detection by carbon nanotube-based near-infrared nanosensors

RL Pinals, F Ledesma, D Yang, N Navarro, S Jeong… - Nano Letters, 2021 - ACS Publications
To effectively track and eliminate COVID-19, it is critical to develop tools for rapid and
accessible diagnosis of actively infected individuals. Here, we introduce a single-walled …

Nanoparticle cellular internalization is not required for RNA delivery to mature plant leaves

H Zhang, NS Goh, JW Wang, RL Pinals… - Nature …, 2022 - nature.com
Rapidly growing interest in the nanoparticle-mediated delivery of DNA and RNA to plants
requires a better understanding of how nanoparticles and their cargoes translocate in plant …

Carbon nanocarriers deliver siRNA to intact plant cells for efficient gene knockdown

GS Demirer, H Zhang, NS Goh, RL Pinals, R Chang… - Science …, 2020 - science.org
Posttranscriptional gene silencing (PTGS) is a powerful tool to understand and control plant
metabolic pathways, which is central to plant biotechnology. PTGS is commonly …

Quantitative protein corona composition and dynamics on carbon nanotubes in biological environments

RL Pinals, D Yang, DJ Rosenberg… - Angewandte Chemie …, 2020 - Wiley Online Library
When nanoparticles enter biological environments, proteins adsorb to form the “protein
corona” which alters nanoparticle biodistribution and toxicity. Herein, we measure protein …

Single-walled carbon nanotube sensor selection for the detection of microrna biomarkers for acute myocardial infarction as a case study

A Hendler-Neumark, V Wulf, G Bisker - ACS sensors, 2023 - ACS Publications
MicroRNAs (miRNAs) are single-stranded non-coding short ribonucleic acid sequences that
take part in many cellular and biological processes. Recent studies have shown that altered …

Enhancing intracellular optical performance and stability of engineered nanomaterials via aqueous two-phase purification

A Nadeem, A Kindopp, I Wyllie, L Hubert, J Joubert… - Nano …, 2023 - ACS Publications
Supramolecular hybrids of DNA and single-walled carbon nanotubes (SWCNTs) have been
introduced in numerous biosensing applications due to their unique optical properties …

Engineering at the nano-bio interface: harnessing the protein corona towards nanoparticle design and function

RL Pinals, L Chio, F Ledesma, MP Landry - Analyst, 2020 - pubs.rsc.org
Unpredictable and uncontrollable protein adsorption on nanoparticles remains a
considerable challenge to achieving effective application of nanotechnologies within …