[HTML][HTML] The extracellular matrix as modifier of neuroinflammation and recovery in ischemic stroke and intracerebral hemorrhage

H Li, S Ghorbani, CC Ling, VW Yong, M Xue - Neurobiology of Disease, 2023 - Elsevier
Stroke is the second leading cause of death worldwide and has two major subtypes:
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …

Electro‐acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of …

YS Zeng, Y Ding, HY Xu, X Zeng… - CNS Neuroscience …, 2022 - Wiley Online Library
The incidence and disability rate of spinal cord injury (SCI) worldwide are high, imposing a
heavy burden on patients. Considerable research efforts have been directed toward …

Ferroptosis contributes to hypoxic–ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway

C Li, Z Wu, H Xue, Q Gao, Y Zhang… - CNS neuroscience & …, 2022 - Wiley Online Library
Aims Hypoxic–ischemic brain injury (HIBI) often results in cognitive impairments. Herein, we
investigated the roles of ferroptosis in HIBI and the underlying signaling pathways. Methods …

Endothelial peroxiredoxin-4 is indispensable for blood–brain barrier integrity and long-term functional recovery after ischemic stroke

N Xu, X Jiang, W Zhang, Y Shi… - Proceedings of the …, 2024 - National Acad Sciences
The endothelial lining of cerebral microvessels is damaged relatively early after cerebral
ischemia/reperfusion (I/R) injury and mediates blood–brain barrier (BBB) disruption …

Aging related impairment of brain microvascular bioenergetics involves oxidative phosphorylation and glycolytic pathways

SSVP Sakamuri, VN Sure, L Kolli… - Journal of Cerebral …, 2022 - journals.sagepub.com
Mitochondrial and glycolytic energy pathways regulate the vascular functions. Aging impairs
the cerebrovascular function and increases the risk of stroke and cognitive dysfunction. The …

Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53‐ALOX15 signaling pathway

D Li, X Lu, G Xu, S Liu, Z Gong, F Lu… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Spinal cord injury (SCI) is a highly disabling condition in spinal surgery that
leads to neuronal damage and secondary inflammation. Ferroptosis is a non‐apoptotic type …

Anti‐neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression‐like behaviors via hypothalamic α7nAchR/JAK2/STAT3/NF‐κB …

Y Chen, Y Zhang, J Wang, S Li, Y Wang… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Transcutaneous auricular vagus nerve stimulation (taVNS) is a vital
neuromodulation for the treatment of depression, but its antidepressant molecular …

Hyperperfusion profiles after recanalization differentially associate with outcomes in a rat ischemic stroke model

BAA Franx, GAF Van Tilborg, A Taha… - Journal of Cerebral …, 2024 - journals.sagepub.com
Futile recanalization hampers prognoses of ischemic stroke after successful mechanical
thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin …

[HTML][HTML] METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis

Y Li, J Li, Q Yu, L Ji, B Peng - Neurobiology of Disease, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) plays a crucial role in ischemic stroke, whereas the role
of methyltransferase-like 14 (METTL14) in ischemic stroke remains unknown. A model of …

An enriched environment improves long-term functional outcomes in mice after intracerebral hemorrhage by mechanisms that involve the Nrf2/BDNF/glutaminase …

P Jia, J Wang, X Ren, J He, S Wang… - Journal of Cerebral …, 2023 - journals.sagepub.com
Post-stroke depression exacerbates neurologic deficits and quality of life. Depression after
ischemic stroke is known to some extent. However, depression after intracerebral …