Proteins are a major target for oxidants as a result of their abundance in biological systems,
and their high rate constants for reaction. Kinetic data for a number of radicals and non …

The ubiquitin–proteasome pathway (UPP) is the primary cytosolic proteolytic machinery for
the selective degradation of various forms of damaged proteins. Thus, the UPP is an …

Biological aging is a fundamental process that represents the major risk factor with respect
to the development of cancer, neurodegenerative, and cardiovascular diseases in …

Oxidative stress in mammalian cells is an inevitable consequence of their aerobic
metabolism. Oxidants produce modifications to proteins leading to loss of function (or gain of …

Oxidatively modified proteins that accumulate in aging and many diseases can form large
aggregates because of covalent cross-linking or increased surface hydrophobicity. Unless …

Sulfur-containing amino acids such as cysteine and methionine are particularly vulnerable
to oxidation. Oxidation of cysteine and methionine in their free amino acid form renders them …

Damage to macromolecules, and in particular protein, implicated in the cellular
degeneration that occurs during the aging process, is corroborated by the accumulation of …

The proteasome is the main protease for degrading oxidized proteins. We asked whether
altered proteasome function contributes to the accumulation of oxidized muscle proteins with …

For years, proteasomal degradation was predominantly attributed to the ubiquitin-26S
proteasome pathway. However, it is now evident that the core 20S proteasome can …

The proteasome is the main proteolytic machinery of the cell and constitutes a recognized
drugable target, in particular for treating cancer. It is involved in the elimination of misfolded …