Targeting senescence as an anticancer therapy
L Bousset, J Gil - Molecular Oncology, 2022 - Wiley Online Library
Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …
Activatable senoprobes and senolytics: Novel strategies to detect and target senescent cells
S Morsli, GJ Doherty, D Muñoz-Espín - Mechanisms of Ageing and …, 2022 - Elsevier
Pharmacologically active compounds that manipulate cellular senescence (senotherapies)
have recently shown great promise in multiple pre-clinical disease models, and some of …
have recently shown great promise in multiple pre-clinical disease models, and some of …
Current and potential roles of immuno-PET/-SPECT in CAR T-cell therapy
A Mulgaonkar, D Udayakumar, Y Yang, S Harris… - Frontiers in …, 2023 - frontiersin.org
Chimeric antigen receptor (CAR) T-cell therapies have evolved as breakthrough treatment
options for the management of hematological malignancies and are also being developed …
options for the management of hematological malignancies and are also being developed …
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
L Mansfield, V Ramponi, K Gupta, T Stevenson… - npj Aging, 2024 - nature.com
Senescence is a crucial hallmark of ageing and a significant contributor to the pathology of
age-related disorders. As committee members of the young International Cell Senescence …
age-related disorders. As committee members of the young International Cell Senescence …