Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

The identification of novel helper T (Th) cell subsets, ie, IL-17-producing Th cells (Th17 cells)
and regulatory T cells (Treg cells), provided new insight into our understanding of the …

Observations of increased numbers of mast cells at sites of chronic inflammation have been
reported for over a hundred years. Light and electron microscopic evidence of mast cell …

Normal human breathing exhibits complex variability in both respiratory rhythm and volume.
Analyzing such nonlinear fluctuations may provide clinically relevant information in patients …

Background Histone acetyltransferases (HAT s) and histone deacetylases (HDAC s)
regulate gene expression, yet differences in the activity of these enzymes in the …

Aims There is limited understanding of how clinical and demographic characteristics are
associated with exacerbation risk in patients with moderate‐to‐severe asthma, and how …

Background: The role of neutrophils in exacerbations of asthma is poorly understood. We
examined the effect of withdrawal of inhaled corticosteroids on sputum inflammatory indexes …

In this study, TNF-α was found to activate the WNT/β-catenin pathway in BEAS-2B human
bronchial epithelial cells. Levels of phospho-LRP6, Dvl-2, and phospho-GSK-3β were …

FeNO measurement is a validated non-invasive technique, which is used for diagnosis and
monitoring of asthma. It would be desirable to find a reliable method to monitor allergic …

Purpose The efficacy of postoperative oral corticosteroids on surgical outcomes in chronic
rhinosinusitis with nasal polyps (CRSwNP) patients following endoscopic sinus surgery …