Recent progress in the discovery and design of antimicrobial peptides using traditional machine learning and deep learning

J Yan, J Cai, B Zhang, Y Wang, DF Wong, SWI Siu - Antibiotics, 2022 - mdpi.com
Antimicrobial resistance has become a critical global health problem due to the abuse of
conventional antibiotics and the rise of multi-drug-resistant microbes. Antimicrobial peptides …

Deep learning tools to accelerate antibiotic discovery

A Cesaro, M Bagheri, M Torres, F Wan… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction As machine learning (ML) and artificial intelligence (AI) expand to many
segments of our society, they are increasingly being used for drug discovery. Recent deep …

AIPs-SnTCN: Predicting anti-inflammatory peptides using fastText and transformer encoder-based hybrid word embedding with self-normalized temporal …

A Raza, J Uddin, A Almuhaimeed, S Akbar… - Journal of chemical …, 2023 - ACS Publications
Inflammation is a biologically resistant response to harmful stimuli, such as infection,
damaged cells, toxic chemicals, or tissue injuries. Its purpose is to eradicate pathogenic …

cACP-DeepGram: classification of anticancer peptides via deep neural network and skip-gram-based word embedding model

S Akbar, M Hayat, M Tahir, S Khan, FK Alarfaj - Artificial intelligence in …, 2022 - Elsevier
Cancer is a Toxic health concern worldwide, it happens when cellular modifications cause
the irregular growth and division of human cells. Several traditional approaches such as …

iAFPs-EnC-GA: identifying antifungal peptides using sequential and evolutionary descriptors based multi-information fusion and ensemble learning approach

A Ahmad, S Akbar, M Tahir, M Hayat, F Ali - Chemometrics and Intelligent …, 2022 - Elsevier
Fungal infections have become a serious health concern for human beings worldwide.
Fungal infections usually occur when the invading fungus appear on a particular part of the …

iAtbP-Hyb-EnC: Prediction of antitubercular peptides via heterogeneous feature representation and genetic algorithm based ensemble learning model

S Akbar, A Ahmad, M Hayat, AU Rehman… - Computers in Biology …, 2021 - Elsevier
Tuberculosis (TB) is a worldwide illness caused by the bacteria Mycobacterium tuberculosis.
Owing to the high prevalence of multidrug-resistant tuberculosis, numerous traditional …

StackedEnC-AOP: prediction of antioxidant proteins using transform evolutionary and sequential features based multi-scale vector with stacked ensemble learning

G Rukh, S Akbar, G Rehman, FK Alarfaj, Q Zou - BMC bioinformatics, 2024 - Springer
Background Antioxidant proteins are involved in several biological processes and can
protect DNA and cells from the damage of free radicals. These proteins regulate the body's …

AFP-CMBPred: Computational identification of antifreeze proteins by extending consensus sequences into multi-blocks evolutionary information

F Ali, S Akbar, A Ghulam, ZA Maher, A Unar… - Computers in Biology …, 2021 - Elsevier
In extremely cold environments, living organisms like plants, animals, fishes, and microbes
can die due to the intracellular ice formation in their bodies. To sustain life in such cold …

Deep-AntiFP: Prediction of antifungal peptides using distanct multi-informative features incorporating with deep neural networks

A Ahmad, S Akbar, S Khan, M Hayat, F Ali… - Chemometrics and …, 2021 - Elsevier
World widely, Fungal infections have become a serious issue for human beings. Fungal
infections normally happen once invading fungus appear on a specific area of the body and …

iHBP-DeepPSSM: Identifying hormone binding proteins using PsePSSM based evolutionary features and deep learning approach

S Akbar, S Khan, F Ali, M Hayat, M Qasim… - … and Intelligent Laboratory …, 2020 - Elsevier
Hormone binding proteins (HBPs) are soluble carrier proteins that can non-covalently and
selectively interact with the human hormone. HBPs plays a significant role in human life, but …