Conformational diseases are caused by mutations altering the folding pathway or final
conformation of a protein. Many conformational diseases are caused by mutations in …

Among membrane‐bound receptors, the G protein‐coupled receptors (GPCRs) are certainly
the most diverse. They have been very successful during evolution, being capable of …

The sense of taste provides animals with valuable information about the quality and
nutritional value of food. Previously, we identified a large family of mammalian taste …

The unanticipated involvement of several intraflagellar transport proteins in the mammalian
Hedgehog (Hh) pathway has hinted at a functional connection between cilia and Hh signal …

Bitter taste perception provides animals with critical protection against ingestion of
poisonous compounds. In the accompanying paper, we report the characterization of a large …

Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory
hubs for a variety of signal transduction pathways. Despite having a conserved basic …

C. elegans has a highly developed chemosensory system that enables it to detect a wide
variety of volatile (olfactory) and water-soluble (gustatory) cues associated with food …

The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

Drosophila olfactory sensory neurons (OSNs) each express two odorant receptors (ORs): a
divergent member of the OR family and the highly conserved, broadly expressed receptor …

G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …