A global review on short peptides: frontiers and perspectives

V Apostolopoulos, J Bojarska, TT Chai, S Elnagdy… - Molecules, 2021 - mdpi.com
Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Peptides as a platform for targeted therapeutics for cancer: Peptide–drug conjugates (PDCs)

BM Cooper, J Iegre, DH O'Donovan… - Chemical society …, 2021 - pubs.rsc.org
Peptides can offer the versatility needed for a successful oncology drug discovery approach.
Peptide–drug conjugates (PDCs) are an emerging targeted therapeutic that present …

Foundations of gastrointestinal-based drug delivery and future developments

JN Chu, G Traverso - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Gastrointestinal-based drug delivery is considered the preferred mode of drug
administration owing to its convenience for patients, which improves adherence. However …

Cyclic peptide drugs approved in the last two decades (2001–2021)

H Zhang, S Chen - RSC Chemical Biology, 2022 - pubs.rsc.org
In contrast to the major families of small molecules and antibodies, cyclic peptides, as a
family of synthesizable macromolecules, have distinct biochemical and therapeutic …

E3 ligase ligands for PROTACs: how they were found and how to discover new ones

T Ishida, A Ciulli - … Advancing the Science of Drug Discovery, 2021 - journals.sagepub.com
Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are
a new modality of chemical tools and potential therapeutics to understand and treat human …

Macrocyclic peptides as drug candidates: recent progress and remaining challenges

AA Vinogradov, Y Yin, H Suga - Journal of the American Chemical …, 2019 - ACS Publications
Peptides as a therapeutic modality attract much attention due to their synthetic accessibility,
high degree of specific binding, and the ability to target protein surfaces traditionally …

Understanding cell penetration of cyclic peptides

PG Dougherty, A Sahni, D Pei - Chemical Reviews, 2019 - ACS Publications
Approximately 75% of all disease-relevant human proteins, including those involved in
intracellular protein–protein interactions (PPIs), are undruggable with the current drug …

The current state of peptide drug discovery: back to the future?

A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

The importance of synthetic chemistry in the pharmaceutical industry

KR Campos, PJ Coleman, JC Alvarez, SD Dreher… - Science, 2019 - science.org
BACKGROUND Over the past century, innovations in synthetic chemistry have greatly
enabled the discovery and development of important life-changing medicines, improving the …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …