Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic
membrane coupling regions formed by the coupling of the mitochondrial outer membrane …

Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Significance: Mitochondria-Associated Membranes (MAMs) are highly dynamic endoplasmic
reticulum (ER)-mitochondria contact sites that, due to the transfer of lipids and Ca2+ …

ABSTRACT Introduction: The sigma-1 receptor (S1R) is attracting much attention for disease-
modifying therapies in neurodegenerative diseases. It is a conserved protein, present in …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and
lower motor neurons. As a consequence, ALS patients display a locomotor disorder related …

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …

Calcium (Ca2+) is a versatile secondary messenger involved in the regulation of a plethora
of different signaling pathways for cell maintenance. Specifically, intracellular Ca2+ …

Abstract The sigma-1 receptor (Sig-1R) is encoded by the SIGMAR1 gene and is a
nonopioid transmembrane receptor located in the mitochondrial-associated endoplasmic …

Abstract Sigma-1 receptor (Sig-1R) is a protein present in several organs such as brain,
lung, and heart. In a cell, Sig-1R is mainly located across the membranes of the …