Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a
major cause of morbidity and mortality. The circadian timing system consists of a central …

Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the
idea that a molecular clock is necessary for metabolic homeostasis. However, these mice …

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

Obesity and liver diseases are associated with the disruption of the circadian clock that
orchestrates mammalian physiology to optimize nutrient metabolism and storage. Here, we …

Glioblastomas are highly lethal cancers, containing self-renewing glioblastoma stem cells
(GSC). Here, we show that GSCs, differentiated glioblastoma cells (DGC), and nonmalignant …

Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis,
disruptions of which can lead to metabolic diseases. Whether N 6-methyladenosine (m 6 A) …

The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …

The circadian system serves one of the most fundamental properties present in nearly all
organisms: it generates 24-h rhythms in behavioral and physiological processes and …