Tissues and biofluids are important sources of information used for the detection of diseases
and decisions on patient therapies. There are several accepted methods for preservation of …

There is a pressing need to improve risk stratification and treatment selection for HPV-
negative head and neck squamous cell carcinoma (HNSCC) due to the adverse side effects …

Proteomic analysis by mass spectrometry of small (≤ 2 mg) solid tissue samples from
diverse formats requires high throughput and comprehensive proteome coverage. We …

Ectopic fat deposition (EFD) in the kidney has been shown to play a causal role in diabetic
nephropathy; however, the mechanism underlying EFD remains elusive. By transcriptome …

Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) is a
common molecular imaging modality used to characterise the abundance and spatial …

Aberrant activation of Ras/Raf/mitogen-activated protein kinase (MAPK) signaling is
frequently linked to metastatic prostate cancer (PCa); therefore, the characterization of …

Recent advances in the field of proteomics have allowed extensive insights into the
molecular regulations of the cell proteome. Specifically, this allows researchers to dissect a …

Immunofluorescence is an important immunochemical technique that utilizes fluorescence-
labeled antibodies to detect specific target antigens. It is used widely in both scientific …

We have developed a streamlined proteomic sample preparation protocol termed
Accelerated Barocycler Lysis and Extraction (ABLE) that substantially reduces the time and …

Abstract Background Prostate cancer (PCa) is the most frequently diagnosed non-skin
cancer and a leading cause of mortality among males in developed countries. However, our …