[HTML][HTML] A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

[HTML][HTML] Organ-on-a-chip: Recent breakthroughs and future prospects

Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

YS Zhang, J Aleman, SR Shin, T Kilic… - Proceedings of the …, 2017 - National Acad Sciences
Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models
designed to recapitulate the important biological and physiological parameters of their in …

In-line analysis of organ-on-chip systems with sensors: Integration, fabrication, challenges, and potential

S Fuchs, S Johansson, AØ Tjell, G Werr… - ACS Biomaterials …, 2021 - ACS Publications
Organ-on-chip systems are promising new in vitro research tools in medical,
pharmaceutical, and biological research. Their main benefit, compared to standard cell …

[HTML][HTML] Microfluidic integration of regeneratable electrochemical affinity-based biosensors for continual monitoring of organ-on-a-chip devices

J Aleman, T Kilic, LS Mille, SR Shin, YS Zhang - Nature Protocols, 2021 - nature.com
Organs-on-chips have emerged as viable platforms for drug screening and personalized
medicine. While a wide variety of human organ-on-a-chip models have been developed …

Organ‐on‐a‐chip platforms: a convergence of advanced materials, cells, and microscale technologies

S Ahadian, R Civitarese, D Bannerman… - Advanced …, 2018 - Wiley Online Library
Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

[HTML][HTML] Measurement and analysis of cancer biomarkers based on electrochemical biosensors

F Cui, Z Zhou, HS Zhou - Journal of The Electrochemical Society, 2019 - iopscience.iop.org
Cancer is a dreadful disease with a high mortality rate, and it has become more and more
prevalent worldwide. Early diagnosis, prognosis and treatment monitoring with robust and …

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

K Moshksayan, N Kashaninejad, ME Warkiani… - Sensors and Actuators B …, 2018 - Elsevier
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …

Recent advances in electrochemical immunosensors

W Wen, X Yan, C Zhu, D Du, Y Lin - Analytical chemistry, 2017 - ACS Publications
Due to the combination of specific antigen− antibody recognition with the high sensitivity of
electrochemical methods, electrochemical immunosensors (EIs) have aroused considerable …

[HTML][HTML] Gut-on-a-chip: Mimicking and monitoring the human intestine

D Marrero, F Pujol-Vila, D Vera, G Gabriel, X Illa… - Biosensors and …, 2021 - Elsevier
Over the last few years, the intestine has been extensively studied using in vitro microfluidic
systems, commonly known as gut-on-a-chip (GOC) devices. This interest has been due not …