[HTML][HTML] Extracellular matrix-cell interactions: Focus on therapeutic applications

A Sainio, H Järveläinen - Cellular signalling, 2020 - Elsevier
Extracellular matrix (ECM) macromolecules together with a multitude of different molecules
residing in the extracellular space play a vital role in the regulation of cellular phenotype and …

Hyaluronic acid biomaterials for central nervous system regenerative medicine

G Jensen, JL Holloway, SE Stabenfeldt - Cells, 2020 - mdpi.com
Hyaluronic acid (HA) is a primary component of the brain extracellular matrix and functions
through cellular receptors to regulate cell behavior within the central nervous system (CNS) …

[HTML][HTML] Oxidative damage to hyaluronan–CD44 interactions as an underlying mechanism of action of oxidative stress-inducing cancer therapy

M Yusupov, A Privat-Maldonado, RM Cordeiro… - Redox biology, 2021 - Elsevier
Multiple cancer therapies nowadays rely on oxidative stress to damage cancer cells. Here
we investigated the biological and molecular effect of oxidative stress on the interaction …

The scrambled story between hyaluronan and glioblastoma

MA Pibuel, D Poodts, M Díaz, SE Hajos… - Journal of Biological …, 2021 - ASBMB
Advances in cancer biology are revealing the importance of the cancer cell
microenvironment on tumorigenesis and cancer progression. Hyaluronan (HA), the main …

The role of RHAMM in cancer: Exposing novel therapeutic vulnerabilities

JA Hinneh, JL Gillis, NL Moore, LM Butler… - Frontiers in …, 2022 - frontiersin.org
Receptor for hyaluronic acid-mediated motility (RHAMM) is a cell surface receptor for
hyaluronic acid that is critical for cell migration and a cell cycle protein involved in …

Glioma stem cells in pediatric high-grade gliomas: from current knowledge to future perspectives

MA Da-Veiga, B Rogister, A Lombard, V Neirinckx… - Cancers, 2022 - mdpi.com
Simple Summary Pediatric high-grade glioma (pHGG) has a dismal prognosis in which the
younger the patient, the more restricted the treatments are, in regard to the incurred risks …

Hyaluronan in the tumor microenvironment

FM Spinelli, DL Vitale, I Sevic, L Alaniz - … : Extracellular Matrix Components …, 2020 - Springer
The extracellular matrix is part of the microenvironment and its functions are associated with
the physical and chemical properties of the tissue. Among the extracellular components, the …

Hyaluronan‐based hydrogels as versatile tumor‐like models: Tunable ECM and stiffness with genipin‐crosslinking

S Bonnesœur, S Morin‐Grognet… - … Research Part A, 2020 - Wiley Online Library
Abstract Three‐dimensional (3D) biomimetic cell culture platforms offer more realistic
microenvironments that cells naturally experience in vivo. We developed a tunable …

Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis

AA Shimpi, ML Tan, M Vilkhovoy, D Dai… - Advanced …, 2023 - Wiley Online Library
Metastasis is the leading cause of breast cancer‐related deaths and is often driven by
invasion and cancer‐stem like cells (CSCs). Both the CSC phenotype and invasion are …

Glycomaterials to investigate the functional role of aberrant glycosylation in Glioblastoma

C Tondepu, L Karumbaiah - Advanced healthcare materials, 2022 - Wiley Online Library
Glioblastoma (GBM) is a stage IV astrocytoma that carries a dismal survival rate of≈ 10
months postdiagnosis and treatment. The highly invasive capacity of GBM and its ability to …