The cardiac glycosides are a group of compounds isolated from plants and some animals.
They have been used in therapy for heart failure for many years. The cytotoxic effect of many …

Ion and water channels were recently shown to be involved in cancer cell functions, and
various transporter types have been detected in upper gastrointestinal tract (UGI) cancers …

Oleanolic acid (OA) is a naturally occurring pentacyclic triterpenoid and possesses diverse
pharmacological activities, including anti-cancer effects that have been confirmed in multiple …

Na+/H+ exchangers (NHEs) are expressed in virtually all human tissues and organs. Two
major tasks of those NHE isoforms that are located in plasma membranes are cell volume …

The mammalian growth factor erv1-like (GFER) gene encodes a sulfhydryl oxidase enzyme,
named Augmenter of Liver Regeneration (ALR). Recently it has been demonstrated that …

Natural products offer an abundant source of diverse novel scaffolds that inspires
development of next generation anti-malarials. With this vision, a library of scaffolds inspired …

Over the last two decades, the understanding of how dysregulated ion channels and
transporters are involved in carcinogenesis and tumor growth and progression, including …

Impaired esophageal mucosal integrity may be an important contributor in the
pathophysiology of gastroesophageal reflux disease (GERD). Nevertheless, the effect of …

Many studies have demonstrated changes in the levels of several ions during apoptosis, but
a few recent studies have reported conflicting results concerning the changes in water …

BACKGROUND AND AIMS: Inflammation plays an important role in the development of
esophageal adenocarcinoma and its metaplastic precursor lesion, Barrett's esophagus. Toll …