RNA interference (RNAi) plays pleiotropic roles in animal cells, from the post-transcriptional
control of gene expression via the production of micro-RNAs, to the inhibition of RNA virus …

PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that bind to the PIWI subclass
of the Argonaute protein family and are essential for maintaining germline integrity. Initially …

Aging is a multifactorial process characterized by an age-related decline in organismal
fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular …

Increasing evidence reinforces the essential function of RNA modifications in development
and diseases, especially in the nervous system. RNA modifications impact various …

PIWI-interacting RNAs (piRNAs), a class of small non-coding RNAs (sncRNAs) with 24–32
nucleotides (nt), were initially identified in the reproductive system. Unlike microRNAs …

Since Joseph Altman published his pioneering work demonstrating neurogenesis in the
hippocampus of adult rats, the number of publications in this field increased exponentially …

Long considered active only in the germline, the PIWI/piRNA pathway is now known to play
a significant role in somatic cells, especially neurons. In this study, piRNAs were profiled in …

Diabetic Retinopathy (DR), a leading complication of diabetes mellitus, has long been
considered as a microvascular disease of the retina. However, recent evidence suggests …

Transposable Elements (TEs) are implicated in aging and neurodegenerative disorders, but
the impact of brain TE RNA dynamics on these phenomena is not fully understood …

Although the gene DUSP6 has been implicated as a risk gene for ADHD in recent GWAS
studies, its functional role in the aetiology of the condition remains poorly understood …