Role of plant-derived compounds in the molecular pathways related to inflammation

AJ Olędzka, ME Czerwińska - International Journal of Molecular Sciences, 2023 - mdpi.com
Inflammation is the primary response to infection and injury. Its beneficial effect is an
immediate resolution of the pathophysiological event. However, sustained production of …

Urolithin A's antioxidative, anti-inflammatory, and antiapoptotic activities mitigate doxorubicin-induced liver injury in wistar rats

S Karim, B Madani, AS Burzangi, M Alsieni… - Biomedicines, 2023 - mdpi.com
Human colon microbiota produce a metabolite called urolithin A (URO A) from ellagic acid
and linked compounds, and this metabolite has been demonstrated to have antioxidant, anti …

Lipopolysaccharide exacerbates ketamine-induced psychotic-like behavior, oxidative stress, and neuroinflammation in mice: ameliorative effect of diosmin

AEO Eneni, B Ben-Azu, AM Ajayi… - Journal of Molecular …, 2023 - Springer
Schizophrenia, a neuropsychiatric disorder has been associated with aberrant
neurotransmission affecting behaviors, social preference, and cognition. Limitations in …

Neuroprotective effect of diosmin against chlorpyrifos-induced brain intoxication was mediated by regulating PPAR-γ and NF-κB/AP-1 signals

TH Abd-Elhamid, D Althumairy, HA Zahra… - Food and Chemical …, 2024 - Elsevier
Chlorpyrifos (CPF) is a widely used organophosphate (OP) pesticide. Unfortunately,
pesticides are known to cause neuronal intoxication. Diosmin (DS) is an antioxidant, anti …

Assessment of anticancer properties of cumin seed (Cuminum cyminum) against bone cancer

R Chandrasekaran, M Krishnan, S Chacko… - Frontiers in …, 2023 - frontiersin.org
Introduction Early-life osteosarcoma is associated with severe morbidity and mortality,
particularly affecting young children and adults. The present cancer treatment regimen is …

Geraniol ameliorates doxorubicin-mediated kidney injury through alteration of antioxidant status, inflammation, and apoptosis: potential roles of NF-κB and Nrf2/Ho-1

AF AlAsmari, N Ali, M Alharbi, F Alqahtani, F Alasmari… - Nutrients, 2022 - mdpi.com
Doxorubicin-mediated kidney impairment is a serious problem in cancer treatment.
Accordingly, this work investigated the ability of geraniol to modulate doxorubicin-induced …

Nephroprotective effect of diosmin against sodium arsenite-induced renal toxicity is mediated via attenuation of oxidative stress and inflammation in mice

S Mohtadi, S Shariati, E Mansouri… - Pesticide Biochemistry and …, 2023 - Elsevier
Arsenic compounds, which are used in different industries like pesticide manufacturing,
cause severe toxic effects in almost all organs, including the kidneys. Since the primary …

[HTML][HTML] Doxorubicin-induced hepatic toxicity in rats: Mechanistic protective role of Omega-3 fatty acids through Nrf2/HO-1 activation and PI3K/Akt/GSK-3β axis …

DO Saleh, SS Mahmoud, A Hassan… - Saudi Journal of Biological …, 2022 - Elsevier
Doxorubicin (DOX), a common antibiotic used to treat a variety of tumors, has several
substantial adverse effects that limit its clinical use. As a result, finding effective protective …

Creatine supplementation potentiates exercise protective effects against doxorubicin-induced hepatotoxicity in mice

LRL Costa Godinho, PS Cella, TAS Guimarães… - Antioxidants, 2023 - mdpi.com
We tested the hypothesis that creatine supplementation may potentiate exercise's protective
effects against doxorubicin-induced hepatotoxicity. Thirty-eight Swiss mice were randomly …

Co-Treatment With Resveratrol and FGF1 Protects Against Acute Liver Toxicity After Doxorubicin Treatment via the AMPK/NRF2 Pathway

X Xu, Q Liu, J Li, M Xiao, T Gao, X Zhang… - Frontiers in …, 2022 - frontiersin.org
Doxorubicin (DOX), an anthracycline type of chemotherapy, is an effective therapy for
several types of cancer, but serious side effects, such as severe hepatotoxicity, limit its use …