Tailoring porous silicon for biomedical applications: from drug delivery to cancer immunotherapy

W Li, Z Liu, F Fontana, Y Ding, D Liu… - Advanced …, 2018 - Wiley Online Library
In the past two decades, porous silicon (PSi) has attracted increasing attention for its
potential biomedical applications. With its controllable geometry, tunable nanoporous …

Cefazolin encapsulated UIO-66-NH2 nanoparticles enhance the antibacterial activity and biofilm inhibition against drug-resistant S. aureus: In vitro and in vivo studies

A Dastneshan, S Rahiminezhad, MN Mezajin… - Chemical Engineering …, 2023 - Elsevier
Antibiotics, which are crucial to treat or prevent bacterial infections, are compounds used to
kill or slow down the growth of bacteria. In recent years, antibiotic resistance has grown into …

Post-nano strategies for drug delivery: multistage porous silicon microvectors

A Venuta, J Wolfram, H Shen, M Ferrari - Journal of Materials …, 2017 - pubs.rsc.org
Nanodelivery systems usually improve the biodistribution of drugs, leading to reduced side
effects and enhanced therapeutic efficacy. However, only a small portion of the injected …

3D printed Polycaprolactone scaffolds with dual macro-microporosity for applications in local delivery of antibiotics

LE Visscher, HP Dang, MA Knackstedt… - Materials science and …, 2018 - Elsevier
Advanced scaffolds used in tissue regenerating applications should be designed to address
clinically relevant complications such as surgical site infection associated with surgical …

Novel antibiotic-loaded point-of-care implant coating inhibits biofilm

JA Jennings, DP Carpenter, KS Troxel… - Clinical Orthopaedics …, 2015 - journals.lww.com
Background Orthopaedic biomaterials are susceptible to biofilm formation. A novel lipid-
based material has been developed that may be loaded with antibiotics and applied as an …

Cefazolin loaded oxidized regenerated cellulose/polycaprolactone bilayered composite for use as potential antibacterial dural substitute

A Sanpakitwattana, W Suvannapruk, S Chumnanvej… - Polymers, 2022 - mdpi.com
Oxidized regenerated cellulose/polycaprolactone bilayered composite (ORC/PCL bilayered
composite) was investigated for use as an antibacterial dural substitute. Cefazolin at the …

Aminopropyl-functionalized mesoporous silica SBA-15 as drug carrier for cefazolin: adsorption profiles, release studies, and mineralization potential

A Szewczyk, M Prokopowicz, W Sawicki… - Microporous and …, 2019 - Elsevier
In this study, the effect of 3-aminopropyl surface functionalization of ordered mesoporous
silica SBA-15 on cefazolin adsorption and release profiles was investigated. The …

pH-triggered controllable release of silver–indole-3 acetic acid complexes from mesoporous silica nanoparticles (IBN-4) for effectively killing malignant bacteria

Y Kuthati, RK Kankala, SX Lin, CF Weng… - Molecular …, 2015 - ACS Publications
An efficient approach for the antimicrobial agent delivery specifically at acidic pH has been
proposed. At the outset, functionalized mesoporous nanoparticles (NPs) were examined to …

Multistage vector (MSV) therapeutics

J Wolfram, H Shen, M Ferrari - Journal of Controlled Release, 2015 - Elsevier
One of the greatest challenges in the field of medicine is obtaining controlled distribution of
systemically administered therapeutic agents within the body. Indeed, biological barriers …

Nanoantibiotics: a new paradigm for the treatment of surgical infection

JS Fernandez-Moure, M Evangelopoulos, K Colvill… - …, 2017 - Taylor & Francis
Infections following orthopedic device implantations often impose a substantial health
burden and result in high medical costs. Currently, preventative methods are often employed …