Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …

Several of the growth factors and their receptor tyrosine kinases (RTK) such as epidermal
growth factor (EGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) …

Alzheimer's disease (AD) is characterized by a robust inflammatory response elicited by the
accumulation and deposition of amyloid-β (Aβ) within the brain. Aβ induces detrimental …

The signaling pathways of mammalian Toll-like receptors (TLRs) are well characterized, but
the precise mechanism (s) by which TLRs are activated upon ligand binding remains poorly …

Hepatocellular carcinoma (HCC) is an extremely metastatic tumor. Sialic acids (SAs) are
associated with cancer development and metastasis. NEU4 is a sialidase that removes SAs …

Epidermal growth factor (EGF)-induced EGFR tyrosine kinase receptor activation in cancer
cell survival responses has become a strategic molecular-targeting clinical therapeutic …

Mammalian neuraminidases (NEUs), also known as sialidases, are enzymes that cleave off
the terminal neuraminic, or sialic, acid resides from the carbohydrate moieties of glycolipids …

Glioblastoma multiforme (GBM) is one of the most devastating brain tumors with median
survival of one year and presents unique challenges to therapy because of its aggressive …

The precise mechanism (s) by which intracellular TOLL-like receptors (TLRs) become
activated by their ligands remains unclear. Here, we report a molecular organizational G …

Neurotrophin-induced Trk tyrosine kinase receptor activation and neuronal cell survival
responses have been reported to be under the control of a membrane associated sialidase …