[HTML][HTML] The outstanding antitumor capacity of CD4+ T helper lymphocytes
Over the past decades, tumor-resident immune cells have been extensively studied to
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …
Mammalian target of rapamycin (mTOR) signaling pathway and traumatic brain injury: A novel insight into targeted therapy
Traumatic brain injury (TBI) is one of the most concerning health issues in which the normal
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
brain function may be disrupted as a result of a blow, bump, or jolt to the head. Loss of …
Distinct prognostic value of circulating anti-telomerase CD4+ Th1 immunity and exhausted PD-1+/TIM-3+ T cells in lung cancer
C Laheurte, M Dosset, D Vernerey, L Boullerot… - British journal of …, 2019 - nature.com
Background Despite the critical roles of Th1-polarised CD4+ T cells in cancer
immunosurveillance, the translation of their potential to clinical use remains challenging …
immunosurveillance, the translation of their potential to clinical use remains challenging …
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates PD-L1 levels in human cancer cells through enhancing protein stabilization accompanied with …
L Deng, G Qian, S Zhang, H Zheng, S Fan, GB Lesinski… - Oncogene, 2019 - nature.com
The involvement of mammalian target of rapamycin (mTOR) in the positive regulation of
oncogenesis has been well documented and thus mTOR has emerged as an attractive …
oncogenesis has been well documented and thus mTOR has emerged as an attractive …
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
SY Sun - Frontiers of Medicine, 2021 - Springer
The mammalian target of rapamycin (mTOR) critically regulates several essential biological
functions, such as cell growth, metabolism, survival, and immune response by forming two …
functions, such as cell growth, metabolism, survival, and immune response by forming two …
A novel mTORC1/2 inhibitor (MTI-31) inhibits tumor growth, epithelial–mesenchymal transition, metastases, and improves antitumor immunity in preclinical models of …
Q Zhang, Y Zhang, Y Chen, J Qian, X Zhang… - Clinical Cancer Research, 2019 - AACR
Purpose: We aimed to investigate efficacy and mechanism of MTI-31 (LXI-15029), a novel
mTORC1/mTORC2 inhibitor currently in human trial (NCT03125746), in non–small cell lung …
mTORC1/mTORC2 inhibitor currently in human trial (NCT03125746), in non–small cell lung …
Barriers to immunotherapy in ovarian cancer: metabolic, genomic, and immune perturbations in the tumour microenvironment
RL Johnson, M Cummings, A Thangavelu… - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapy hinges on stimulating patients' immune system to fight
cancer. This treatment has led to improved survival in patients with malignancies such as …
cancer. This treatment has led to improved survival in patients with malignancies such as …
mTOR Signaling pathway as a master regulator of memory CD8+ T‐cells, Th17, and NK cells development and their functional properties
D Rostamzadeh, M Yousefi… - Journal of Cellular …, 2019 - Wiley Online Library
The mammalian target of rapamycin (mTOR) is a member of the evolutionary
phosphatidylinositol kinase‐related kinases (PIKKs). mTOR plays a pivotal role in the …
phosphatidylinositol kinase‐related kinases (PIKKs). mTOR plays a pivotal role in the …
Combining mTOR inhibitors and T cell-based immunotherapies in cancer treatment
A El Hage, O Dormond - Cancers, 2021 - mdpi.com
Simple Summary Several clinical protocols are exploring the anticancer effect of
immunotherapy combined to targeted therapy. Indeed, emerging evidence demonstrates …
immunotherapy combined to targeted therapy. Indeed, emerging evidence demonstrates …
Mechanistic target of rapamycin inhibitors in renal cell carcinoma: potential, limitations, and perspectives
S Faes, N Demartines, O Dormond - Frontiers in Cell and …, 2021 - frontiersin.org
Several elements highlight the importance of the mechanistic target of rapamycin (mTOR) in
the biology of renal cell carcinoma (RCC). mTOR signaling pathway is indeed frequently …
the biology of renal cell carcinoma (RCC). mTOR signaling pathway is indeed frequently …