Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Chemokines and chemokine receptors orchestrate cell migration and homing in the body.
Humans have at least 44 chemokines that are further classified into four subfamilies based …

The adoption of the concept that asthma is primarily a disease most frequently associated
with elaboration of T‐helper 2 (Th2)‐type inflammation has led to the widely held concept …

Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …

Current therapies for asthma and allergy are relatively safe and effective at controlling
symptoms but do not change the chronic course of disease. There is no established method …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Effective treatment of severe asthma is a major unmet need because patients' symptoms are
not controlled on maximum treatment with inhaled therapy. Asthma symptoms can be poorly …

Asthma is a heterogeneous inflammatory disease of the airways that is associated with
airway hyperresponsiveness and airflow limitation. Although asthma was once simply …

Current asthma therapy is based on the use of adrenergic bronchodilator and anti-
inflammatory drugs the specificity, efficacy, duration of action, and safety of which have been …

Targeted therapeutics such as monoclonal antibodies (mAbs) have proven successful as
cancer drugs. To profile products that could be marketed in the future, we examined the …