The barrier function of the skin is primarily located in the stratum corneum (SC), the
outermost layer of the skin. The SC is composed of dead cells with highly organized lipid …

The multifaceted role of biological membranes prompted early the development of artificial
lipid-based models with a primary view of reconstituting the natural functions in vitro so as to …

Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …

Ceramides, members of sphingolipid family, are not only the building blocks of epidermal
barrier structure, but also bioactive metabolites involved in epidermal self-renewal and …

Mammalian epidermis is a striking example of the role of lipids in tissue biology. In this
stratified epithelium, highly specialized structures are formed that leverage the hydrophobic …

The menopause can lead to epidermal changes that are alleviated by hormone replacement
therapy (HRT). We hypothesise that these changes could relate to altered ceramide …

The intercellular lipid matrix of the stratum corneum (SC), which consist mainly of ceramides
(CERs), free fatty acids and cholesterol, is fundamental to the skin barrier function. These …

The in vitro skin penetration of pharmaceutical or cosmetic ingredients is usually assessed
in human or animal tissue. However, there are ethical and practical difficulties associated …

The Stratum corneum (SC) prevents water loss from the body and absorption of chemicals.
SC intercellular spaces contain ceramides (Cer), free fatty acids (FFA), cholesterol (Chol) …

This review is focused on sphingolipid backbone hydroxylation, a small but widespread
structural feature with profound impact on membrane biophysical properties. We start by …