Since the proposition of the pro‐invasive activity of proteolytic enzymes over 70 years ago,
several roles for proteases in cancer progression have been established. About half of the …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease
inhibitor of trypsin in the pancreas. However, emerging evidence shows its function in …

The purpose of the current work was to utilize a three dimensional (3D) corneal epithelial
tissue model to study dry eye disease and oxidative stress-related corneal epithelial injuries …

Background: Neoadjuvant chemotherapy (NAC) has been of recent interest as an alternative
to upfront surgery followed by adjuvant chemotherapy in patients with pancreatic ductal …

The serine protease inhibitor Kazal type (SPINK) family includes SPINK1-14 and is the
largest branch in the serine protease inhibitor family. SPINKs play an important role in …

(1) The serine protease inhibitor Kazal type 1 (SPINK1) inhibits trypsin activity in zymogen
granules of pancreatic acinar cells. Several mutations in the SPINK1 gene are associated …

There is an urgent need for the identification as well as clinicopathological and functional
characterization of potent prognostic biomarkers and therapeutic targets in acute myeloid …

Objective This study aimed to investigate the expression of serine protease inhibitor kazal
type 1 (SPINK1) and its carcinogenic effect in oral tongue squamous cell carcinoma …

Protease temporary inhibitors are true substrates that bind the catalytic site with high affinity
but are slowly degraded, thus acting as inhibitor for a defined time window. Serine peptidase …