Nanoemulsion: Concepts, development and applications in drug delivery

Y Singh, JG Meher, K Raval, FA Khan… - Journal of controlled …, 2017 - Elsevier
Nanoemulsions are biphasic dispersion of two immiscible liquids: either water in oil (W/O) or
oil in water (O/W) droplets stabilized by an amphiphilic surfactant. These come across as …

Nanoemulsions for “nose-to-brain” drug delivery

MC Bonferoni, S Rossi, G Sandri, F Ferrari, E Gavini… - Pharmaceutics, 2019 - mdpi.com
The blood–brain barrier (BBB) plays a fundamental role in protecting the brain from toxic
substances and therefore also controls and restricts the entry of therapeutic agents. The …

Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions

N Rapoport, KH Nam, R Gupta, Z Gao, P Mohan… - Journal of Controlled …, 2011 - Elsevier
Perfluorocarbon nanoemulsions can deliver lipophilic therapeutic agents to solid tumors and
simultaneously provide for monitoring nanocarrier biodistribution via ultrasonography and/or …

Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery …

P Mohan, N Rapoport - Molecular pharmaceutics, 2010 - ACS Publications
Doxorubicin (DOX) is one of the most commonly used chemotherapeutic drugs and is a
popular research tool due to the inherent fluorescence of the DOX molecule. After DOX …

Indocyanine green-loaded photoacoustic nanodroplets: dual contrast nanoconstructs for enhanced photoacoustic and ultrasound imaging

A Hannah, G Luke, K Wilson, K Homan, S Emelianov - ACS nano, 2014 - ACS Publications
Recently, perfluorocarbon (PFC) nanodroplets were introduced as contrast agents for
imaging and image-guided therapy. For example, in sonography, high-intensity ultrasound …

Phase‐shift, stimuli‐responsive perfluorocarbon nanodroplets for drug delivery to cancer

N Rapoport - Wiley Interdisciplinary Reviews: Nanomedicine …, 2012 - Wiley Online Library
This review focuses on phase‐shift perfluorocarbon nanoemulsions whose action depends
on an ultrasound‐triggered phase shift from a liquid to gas state. For drug‐loaded …

Phase-change contrast agents for imaging and therapy

PS Sheeran, PA Dayton - Current pharmaceutical design, 2012 - ingentaconnect.com
Phase-change contrast agents (PCCAs) for ultrasound-based applications have resulted in
novel ways of approaching diagnostic and therapeutic techniques beyond what is possible …

Dye‐loaded nanoemulsions: biomimetic fluorescent nanocarriers for bioimaging and nanomedicine

AS Klymchenko, F Liu, M Collot… - Advanced healthcare …, 2021 - Wiley Online Library
Lipid nanoemulsions (NEs), owing to their controllable size (20 to 500 nm), stability and
biocompatibility, are now frequently used in various fields, such as food, cosmetics …

Characterization of submicron phase-change perfluorocarbon droplets for extravascular ultrasound imaging of cancer

R Williams, C Wright, E Cherin, N Reznik, M Lee… - Ultrasound in medicine …, 2013 - Elsevier
Because many tumors possess blood vessels permeable to particles with diameters of 200
nm, it is possible that submicron perfluorocarbon droplets could constitute a novel …

Investigation of vaporized submicron perfluorocarbon droplets as an ultrasound contrast agent

N Reznik, R Williams, PN Burns - Ultrasound in medicine & biology, 2011 - Elsevier
Acoustically activated submicron droplets of liquid perfluorocarbon are investigated as a
new class of ultrasound contrast agent. In the liquid state, intravascular droplets can …