Soft–hard tissue interfaces in nature present a diversity of hierarchical transitions in
composition and structure to address the challenge of stress concentrations that would …

Living organisms have evolved sophisticated cell-mediated biomineralization mechanisms
to build structurally ordered, environmentally adaptive composite materials. Despite …

Entheses are complex multi-tissue regions of the musculoskeletal system serving the
challenging task of connecting highly dissimilar materials such as the compliant tendon to …

Tendon–bone interface is prevalent in the human body. It is divided into four zones: tendon
(soft tissue), unmineralized fibrocartilage, mineralized fibrocartilage, and bone (hard tissue) …

A demanding task of the musculoskeletal system is the attachment of tendon to bone at
entheses. This region often presents a thin layer of fibrocartilage (FC), mineralized close to …

The meniscus regeneration can present major challenges such as mimicking tissue
microstructuration or triggering cell regeneration. In the case of lesions that require a …

Articular cartilage is a collagen-rich tissue that provides a smooth, lubricated surface for
joints and is also responsible for load bearing during movements. The major components of …

The use of engineered cells, tissues, and organs has the opportunity to change the way
injuries and diseases are treated. Commercialization of these groundbreaking technologies …

Fibrocartilaginous entheses are structurally complex tissues that translate load from elastic
ligaments to stiff bone via complex zonal gradients in the organization, mineralization, and …

Soft‐hard tissue interfaces are widespread in the human body, where matrix stiffness
gradient at the cellular scale is a typical biophysical cue that cells experience. However …