Usually the dense extracellular structure in fibrotic tissues is described as extracellular
matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

Fibrosis in multiple organs is a prominent pathological finding and distinguishing hallmark of
systemic sclerosis (SSc). Findings during the past 5 years have contributed to a more …

The platelet-derived growth factor (PDGF)/PDGFR receptor (PDGFR) family is essential for a
vast array of physiological processes such as migration and proliferation of percityes that …

For about four decades, platelet-derived growth factors (PDGF) and their receptors have
been the subject of intense research, revealing their roles in embryo development and …

Systemic sclerosis (SSc), also known as scleroderma, is a rare connective tissue disease
characterized by vascular and immune dysfunction, leading to fibrosis that can damage …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Background Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue
fibrosis. The renin-angiotensin and endothelin systems have been implicated in …

Autoantibodies directed against a variety of nuclear, cytoplasmic and extracellular
autoantigens are a serological hallmark of systemic sclerosis. This review provides an …

Systemic sclerosis (SSc) is thought to be an autoimmune disease, as autoantibodies against
a variety of extractable nuclear antigens can be detected in patient sera. Subgrouping …