Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

Adult cardiomyocytes exhibit complex Ca2+ homeostasis, enabling tight control of
contraction and relaxation. This intricate regulatory system develops gradually, with …

In heart failure (HF), energy metabolism pathway in cardiac muscle changes from fatty acid β-
oxidation to glycolysis. However, the exact mechanism is unknown. Sarcoendoplasmic …

Background Resveratrol has shown benefits in reducing ventricular remodeling and
arrhythmias. Objective This study aimed to assess the therapeutic efficacy of resveratrol in …

Rationale: Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to
cardiac arrhythmias and heart failure (HF) after myocardial infarction (MI). It has been …

This review highlights recent and ongoing discoveries that are transforming the previously
held view of dyad structure and function. New data show that dyads vary greatly in both …

In many cell types the intracellular Ca2+ store performs a central role in the regulation of the
cytosolic Ca2+ concentration ([Ca2+] c), the elevation of which triggers diverse and …

Aims Cellular processes in the heart rely mainly on studies from experimental animal
models or explanted hearts from patients with terminal end‐stage heart failure (HF). To …

Background Physical exercise attenuates myocardial infarction (MI)-induced cardiac
remodeling. However, it is unsettled whether late exercise modulates post-infarction cardiac …

ABSTRACT HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a
novel cardioprotector against stress-induced injury. We identified a human mutant of HSPB6 …