Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

Colorectal cancer (CRC) has the second highest mortality rate among all cancers
worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment …

In this study, we comprehensively charted the cellular landscape of colorectal cancer (CRC)
and well-matched liver metastatic CRC using single-cell and spatial transcriptome RNA …

Molecular mechanisms underlying breast cancer lymph node metastasis remain unclear.
Using single-cell sequencing, we investigated the transcriptome profile of 96,796 single …

As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

Colorectal cancer (CRC) is a common and deadly disease. Unfortunately, immune
checkpoint inhibitors (ICIs) fail to elicit effective anti-tumour responses in the vast majority of …

Finding new therapeutic approaches towards colorectal cancer (CRC) is of increased
relevance, as CRC is one of the most common cancers worldwide. CRC standard therapy …

An immunosuppressive microenvironment enriched with regulatory CD4+ T lymphocytes
(Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to …

The tumor microenvironment is distinctive in primary and secondary liver cancer. B cells
represent an important component of immune infiltrates. Here, we demonstrated that B cells …

Mucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal
antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides …