Oxidative stress occurs when ROS overproduction overwhelms the elimination ability of
antioxidants. Accumulated studies have found that oxidative stress is regulated by histone …

Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …

In hypoxia and hyperglycemia, SET7/9 plays an important role in controlling HIF-1α
methylation and regulating the transcription of HIF-1α target genes, which are responsible …

Acute kidney injury (AKI) is a collection of clinical syndromes with persistent increases in
morbidity and mortality rates. Hyperglycemia is a risk factor for AKI development. Renin …

Aims The present study aimed at exploring the mechanisms behind Klotho regulation in
hyperglycemia augmented AKI. In addition, epigenetic ways to restore the Klotho expression …

Chronic liver disease (CLD) represents a global health problem, accounting for the heavy
burden of disability and increased health care utilization. Epigenome alterations play an …

Background Hyperglycaemia influences the development of glomerular endothelial cell
damage and nowhere is this more evident than in the progression of diabetic kidney disease …

Chronic kidney disease (CKD) is defined by persistent urine aberrations, structural
abnormalities, or impaired excretory renal function. Diabetes is the leading cause of CKD …

Ferroptosis of the retinal pigment epithelial (RPE) cells leads to retinal neuron injury and
even visual loss. Our study aims to investigate the role of the SET domain with lysine …

A growing body of evidence suggests that low nephron numbers at birth can increase the
risk of chronic kidney disease or hypertension later in life. Environmental stressors, such as …