Cellular homeostasis requires the proper nuclear-cytoplasmic partitioning of large
molecules, which is often deregulated in cancer. XPO1 is an export receptor responsible for …

Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells.
To perform their myriad roles, not only must precise small RNA species be generated, but …

MicroRNAs (miRNAs) are short RNA gene regulators typically produced from primary
transcripts that are cleaved by the nuclear microprocessor complex, with the resulting …

MicroRNAs (miRNAs) comprise a large family of small RNA molecules that post-
transcriptionally regulate gene expression in many biological pathways. Most miRNAs are …

MicroRNAs (miRNAs) are tightly regulated through transcriptional and posttranscriptional
mechanisms, including degradation by nucleases. Here, we report that in C. elegans, target …

The highly conserved let-7 microRNA (miRNA) regulates developmental pathways across
animal phyla. Mis-expression of let-7 causes lethality in C. elegans and has been …

Approximately 22 nucleotide-long non-coding small RNAs (ncRNAs) play crucial roles in
physiological and pathological activities, including microRNAs (miRNAs). Long ncRNAs …

MicroRNAs are small, noncoding RNAs that regulate gene expression at the post-
transcriptional level in essentially all aspects of Caenorhabditis elegans biology. More than …

Transcriptional modulation of the process of autophagy involves the transcription factor HLH-
30/TFEB. In order to systematically determine the regulatory network of HLH-30/TFEB, we …

The reversible state of proliferative arrest known as “cellular quiescence” plays an important
role in tissue homeostasis and stem cell biology. By analyzing the expression of miRNAs …