[HTML][HTML] Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment

X Xu, C Liu, Y Wang, O Koivisto, J Zhou, Y Shu… - Advanced drug delivery …, 2021 - Elsevier
Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …

[HTML][HTML] Safety and efficacy assessment of aerogels for biomedical applications

T Ferreira-Gonçalves, C Constantin, M Neagu… - Biomedicine & …, 2021 - Elsevier
The unique physicochemical properties of aerogels have made them an attractive class of
materials for biomedical applications such as drug delivery, regenerative medicine, and …

Chitosan-capped silver nanoparticles with potent and selective intrinsic activity against the breast cancer cells

AAH Abdellatif, A Abdelfattah, MA Younis… - Nanotechnology …, 2023 - degruyter.com
Herein, we report on the development of chitosan-capped silver nanoparticles (AgNPs-CHI)
with an intrinsic activity against breast cancer cells. Following chemical synthesis via a …

Nanoplatform‐based in vivo gene delivery systems for cancer therapy

R Luo, H Le, Q Wu, C Gong - Small, 2024 - Wiley Online Library
Gene therapy uses modern molecular biology methods to repair disease‐causing genes. As
a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there …

Cyclic RGD-functionalized pH/ROS dual-responsive nanoparticle for targeted breast cancer therapy

P Yao, X Wang, Q Wang, Q Dai, Y Peng, Q Yuan… - Pharmaceutics, 2023 - mdpi.com
Breast cancer is the most common malignant tumor in women and is a big challenge to
clinical treatment due to the high morbidity and mortality. The pH/ROS dual-responsive …

Therapeutic applications of the CRISPR-cas system

K Kang, Y Song, I Kim, TJ Kim - Bioengineering, 2022 - mdpi.com
The clustered regularly interspaced palindromic repeat (CRISPR)-Cas system has
revolutionized genetic engineering due to its simplicity, stability, and precision since its …

Harnessing molecular recognition for localized drug delivery

R Liu, R Zuo, GA Hudalla - Advanced drug delivery reviews, 2021 - Elsevier
A grand challenge in drug delivery is providing the right dose, at the right anatomic location,
for the right duration of time to maximize therapeutic efficacy while minimizing off-target …

[PDF][PDF] Nanostructure-based therapies for liver fibrosis.

DD Zugravu Pop, DR Mitrea, S Suciu… - Journal of Physiology & …, 2020 - jpp.krakow.pl
Nanotechnology has led to the development of numerous new systems for drug delivery into
the target tissue, as well as novel methods that may be useful in the treatment of liver …

Development of novel apoferritin formulations for antitumour benzothiazoles

AF Breen, G Wells, L Turyanska… - Cancer …, 2019 - Wiley Online Library
Background The benzothiazole structure is important in medicinal chemistry, and 5‐fluoro‐2‐
(3, 4‐dimethoxyphenyl) benzothiazole (GW 610) is of particular interest as it shows …

Protein encapsulation of experimental anticancer agents 5f 203 and phortress: towards precision drug delivery

AF Breen, D Scurr, ML Cassioli, G Wells… - International Journal …, 2019 - Taylor & Francis
Introduction Advancement of novel anticancer drugs into clinical use is frequently halted by
their lack of solubility, reduced stability under physiological conditions, and non-specific …