As a promiscuous xenobiotic sensor, pregnane X receptor (PXR) plays a crucial role in drug
metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this …

Introduction: The xenobiotic detoxification system, which protects the human body from
external chemicals, comprises drug-metabolizing enzymes and transporters whose …

Chemotherapy is one of the three most common treatment modalities for cancer. However,
its efficacy is limited by multidrug resistant cancer cells. Drug metabolizing enzymes (DMEs) …

The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two
closely related and liver-enriched nuclear hormone receptors originally defined as …

The pregnane X receptor (PXR), along with its sister receptor constitutive androstane
receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug …

Introduction:'Orphan'nuclear receptors belong to the nuclear receptor (NR) superfamily of
transcriptional factors. Binding of ligands to these receptors results in the recruitment of the …

For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Highlights•PXR and CAR regulate drug disposition and human diseases.•PXR and CAR are
potential drug targets.•Small molecules modulating specific function of PXR or CAR are …

Abstract Background Ziziphi Spinosae Semen (ZSS) is a plant widely used as medicine and
food in Asian countries due to its numerous health benefits. γ-aminobutyric acid (GABA), a …

Cancer remains one of the major leading causes of death worldwide. Acquisition of
multidrug resistance (MDR) remains a major impediment to successful chemotherapy. As …