Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models

C Withaar, CSP Lam, GG Schiattarella… - European heart …, 2021 - academic.oup.com
Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease
accounting for a large and increasing proportion of all clinical HF presentations. As a clinical …

Pathological ventricular remodeling: mechanisms: part 1 of 2

JS Burchfield, M Xie, JA Hill - Circulation, 2013 - Am Heart Assoc
Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …

Sex differences and similarities in atrial fibrillation epidemiology, risk factors, and mortality in community cohorts: results from the BiomarCaRE Consortium (Biomarker …

C Magnussen, TJ Niiranen, FM Ojeda, F Gianfagna… - Circulation, 2017 - Am Heart Assoc
Background: Atrial fibrillation (AF) is a common cardiac disease in aging populations with
high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently …

Differential impact of heart failure with reduced ejection fraction on men and women

P Dewan, R Rørth, PS Jhund, L Shen… - Journal of the American …, 2019 - jacc.org
Background: Heart failure (HF) trials initiated in the last century highlighted many differences
between men and women. Of particular concern was undertreatment of women compared …

Estrogen signaling and cardiovascular disease

E Murphy - Circulation research, 2011 - Am Heart Assoc
Estrogen has pleiotropic effects on the cardiovascular system. The mechanisms by which
estrogen confers these pleiotropic effects are undergoing active investigation. Until a …

Sex-based differences in heart failure across the ejection fraction spectrum: phenotyping, and prognostic and therapeutic implications

D Stolfo, A Uijl, O Vedin, A Strömberg, UL Faxén… - JACC: Heart Failure, 2019 - jacc.org
Objectives: This study assessed sex-related differences in a large cohort of unselected
patients with heart failure (HF) across the ejection fraction (EF) spectrum. Background …

Left ventricular structural remodeling in health and disease: with special emphasis on volume, mass, and geometry

WH Gaasch, MR Zile - Journal of the American College of Cardiology, 2011 - jacc.org
The changes in left ventricular (LV) structure and geometry that evolve after myocardial
injury or overload usually involve chamber dilation and/or hypertrophy. Such architectural …

The fibrosis marker galectin‐3 and outcome in the general population

RA De Boer, DJ Van Veldhuisen… - Journal of internal …, 2012 - Wiley Online Library
de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege
HL, Bakker SJL, van der Harst P (University of Groningen). The fibrosis marker galectin‐3 …

Characterization of the inflammatory‐metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution …

M Packer, CSP Lam, LH Lund… - European Journal of …, 2020 - Wiley Online Library
Accumulating evidence points to the existence of an inflammatory‐metabolic phenotype of
heart failure with a preserved ejection fraction (HFpEF), which is characterized by …

Prevalence and prognostic implications of longitudinal ejection fraction change in heart failure

G Savarese, O Vedin, D D'Amario, A Uijl, U Dahlström… - JACC: Heart Failure, 2019 - jacc.org
Objectives: This study sought to evaluate the incidence, the predictors, and the associations
with outcomes of changes in ejection fraction (EF) in heart failure (HF) patients. Background …