Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a
pathogen of great interest on a global scale. This obligate intracellular airborne pathogen …

Ferritin, a key regulator of iron homeostasis in macrophages, has been reported to confer
host defenses against Mycobacterium tuberculosis (Mtb) infection. Nuclear receptor …

Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …

Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human
body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding …

Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin
on the Mycobacterium tuberculosis redox state were explored to identify strategies for …

Mycobacterium tuberculosis (Mtb) secretes extracellular vesicles (EVs) containing a variety
of proteins, lipoproteins, and lipoglycans. While emerging evidence suggests that EVs …

One key to the success of Mycobacterium tuberculosis as a pathogen is its ability to reside in
the hostile environment of the human macrophage. Bacteria adapt to stress through a variety …

Mycobacterium tuberculosis (Mtb), the cause of the human pulmonary disease tuberculosis
(TB), contributes to approximately 1.5 million deaths every year. Prior work has established …

Iron is an essential factor for the growth and virulence of Mycobacterium tuberculosis (Mtb).
However, little is known about the mechanisms by which the host controls iron availability …