Introduction Drug delivery systems with extended-release profiles are ideal in improving
patient compliance with enhanced efficacy. To develop devices capable of a prolonged …

It has been nearly two decades since RNA‐interference (RNAi) was first reported. While
there are no approved clinical uses, several phase II and III clinical trials suggest the great …

In the current study nano and microparticle engineering of water insoluble drugs was
conducted using a novel piezoelectric spray-drying approach. Cyclosporin A (CyA) and …

The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and
the mandibular condyle which is commonly affected. These affections are often so painful …

The discovery of RNAi in the late 1990s unlocked a new realm of therapeutic possibilities by
enabling potent and specific silencing of theoretically any desired genetic target. Better …

Currently, the most severe limitation to applying RNA interference technology is delivery,
including localizing the molecules to a specific site of interest to target a specific cell …

Osteoarthritis (OA) is a big burden of disease worldwide and one of the most common
causes of disability in the adult population. Currently applied therapies consist of physical …

Abstract Myeloid cell leukemia-1 (Mcl-1), a member of the Bcl-2 anti-apoptotic family, is
overexpressed in the synovial macrophages of patients with rheumatoid arthritis (RA). Small …

The temporomandibular joint disorder, also known as myofascial pain syndrome, is
considered one of the prevalent chronic pain diseases caused by muscle inflammation and …

In this work, PLGA scaffolds with different architectures were fabricated to investigate the
effects of surface area to volume ratio (SVR)(which resulted from the different architectures) …