Small RNA sorting: matchmaking for Argonautes
Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells.
To perform their myriad roles, not only must precise small RNA species be generated, but …
To perform their myriad roles, not only must precise small RNA species be generated, but …
Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production
K Miyoshi, T Miyoshi, H Siomi - Molecular Genetics and Genomics, 2010 - Springer
MicroRNAs (miRNAs) are an abundant class of small non-coding RNAs that collectively
regulate the expression of a large number of mRNAs by either promoting destabilization or …
regulate the expression of a large number of mRNAs by either promoting destabilization or …
Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets
Background tRFs, 14 to 32 nt long single-stranded RNA derived from mature or precursor
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
tRNAs, are a recently discovered class of small RNA that have been found to be present in …
A genome-scale shRNA resource for transgenic RNAi in Drosophila
Existing transgenic RNAi resources in Drosophila melanogaster based on long double-
stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in …
stranded hairpin RNAs are powerful tools for functional studies, but they are ineffective in …
[HTML][HTML] Dicer partner proteins tune the length of mature miRNAs in flies and mammals
Summary Drosophila Dicer-1 produces microRNAs (miRNAs) from pre-miRNA, whereas
Dicer-2 generates small interfering RNAs (siRNAs) from long dsRNA. Alternative splicing of …
Dicer-2 generates small interfering RNAs (siRNAs) from long dsRNA. Alternative splicing of …
Hierarchical rules for Argonaute loading in Drosophila
Summary Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA
content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by …
content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by …
Gene regulation by non-coding RNAs
The past two decades have seen an explosion in research on non-coding RNAs and their
physiological and pathological functions. Several classes of small (20–30 nucleotides) and …
physiological and pathological functions. Several classes of small (20–30 nucleotides) and …
Plant dicer-like proteins: double-stranded RNA-cleaving enzymes for small RNA biogenesis
A Fukudome, T Fukuhara - Journal of Plant Research, 2017 - Springer
Dicer, a double-stranded RNA (dsRNA)-specific endoribonuclease, plays an essential role
in triggering both transcriptional and post-transcriptional gene silencing in eukaryotes by …
in triggering both transcriptional and post-transcriptional gene silencing in eukaryotes by …
Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defense
Abstract Background Small RNA (sRNA) regulatory pathways (SRRPs) are important to anti-
viral defence in mosquitoes. To identify critical features of the virus infection process in …
viral defence in mosquitoes. To identify critical features of the virus infection process in …
The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response
KH Kok, PY Lui, MHJ Ng, KL Siu, SWN Au, DY Jin - Cell host & microbe, 2011 - cell.com
RIG-I, a virus sensor that triggers innate antiviral response, is a DExD/H box RNA helicase
bearing structural similarity with Dicer, an RNase III-type nuclease that mediates RNA …
bearing structural similarity with Dicer, an RNase III-type nuclease that mediates RNA …