Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

The baseline composition of T cells directly affects later response to pathogens, but the
complexity of precursor states remains poorly defined. Here, we examined the baseline state …

Immune memory—comprising T cells, B cells and plasma cells and their secreted antibodies—
is crucial for human survival. It enables the rapid and effective clearance of a pathogen after …

SARS-CoV-2 infection and vaccination generates enormous host-response heterogeneity
and an age-dependent loss of immune-response quality. How the pre-exposure T cell …

Although not being the first viral pandemic to affect humankind, we are now for the first time
faced with a pandemic caused by a coronavirus. The Severe Acute Respiratory Syndrome …

Antigen-specific T cells play a central role in the adaptive immune response and come in a
wide range of phenotypes. T cell receptors (TCRs) mediate the antigen-specificities found in …

We recently developed an immuno-oncotherapy against human papillomavirus (HPV)-
induced tumors based on a lentiviral vector encoding the Early E6 and E7 oncoproteins of …

Vaccine-induced T cells and neutralizing antibodies are essential for protection against
SARS-CoV-2. Previously, we demonstrated that an antigen delivery system, pullulan …

Summary mRNA vaccines against the spike glycoprotein of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) elicit strong T cell responses. However, a clonal …

Although significant advances in immunotherapy have revolutionized the treatment of many
cancer types over the past decade, the field of vaccine therapy, an important component of …